Alcohol consumption is controlled by angiotensin II

ABSTRACT Pharmacological manipulation of the renin‐angiotensin system (RAS) appears to alter voluntary alcohol consumption in animals. We have now addressed the role of angiotensin II (AII) in alcohol intake by comparing the alcohol‐drinking behavior of mice lacking or overexpressing the angiotensin...

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Bibliographic Details
Published in:The FASEB journal 2001-07, Vol.15 (9), p.1640-1642
Main Authors: Maul, Bjoern, Siems, Wolf-Eberhard, Hoehe, Margret R., Grecksch, Gisela, Bader, Michael, Walther, Thomas
Format: Article
Language:English
Subjects:
ACE inhibition
Alcohol Drinking - metabolism
Alcohol Drinking - prevention & control
Angiotensin II - genetics
Angiotensin II - metabolism
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Angiotensinogen - genetics
Angiotensinogen - physiology
Animals
Dopamine Antagonists - therapeutic use
Energy Intake
Gene Transfer Techniques
Mice
Mice, Transgenic
Models, Animal
Peptidyl-Dipeptidase A - metabolism
Receptors, Dopamine - metabolism
spirapril
transgenic mice
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Summary:ABSTRACT Pharmacological manipulation of the renin‐angiotensin system (RAS) appears to alter voluntary alcohol consumption in animals. We have now addressed the role of angiotensin II (AII) in alcohol intake by comparing the alcohol‐drinking behavior of mice lacking or overexpressing the angiotensinogen gene in a two‐bottle choice paradigm. We found that alcohol consumption was directly related to AII levels. Animals harboring a rat angiotensinogen transgene consumed significantly more of the alcoholic beverage than did controls. This effect could be remarkably reduced by spirapril, an inhibitor of the angiotensin‐converting enzyme (ACE). However, mice lacking the angiotensinogen gene exhibited a markedly reduced alcohol intake. These results indicate a role for the angiotensinogen gene in alcohol consumption via modulation of AII.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.00-0797fje