The Role of Intraoperative Radiation Therapy (IORT) in the Treatment of Locally Advanced Gynecologic Malignancies

The prognosis in women with locally advanced primary or recurrent gynecologic malignancies is rather poor. Doses of external beam radiation necessary to treat gross or microscopic recurrence among patients surgically treated or previously irradiated exceed what is tolerated by normal structures. In...

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Bibliographic Details
Published in:The oncologist (Dayton, Ohio) Ohio), 2000, Vol.5 (1), p.18-25
Main Authors: Carmen, Marcela G., McIntyre, James F., Goodman, Annekathryn
Format: Article
Language:English
Subjects:
Adult
Advanced gynecologic malignancies
Aged
Brachytherapy
Combined Modality Therapy
External beam radiation therapy
Female
Genital Neoplasms, Female - pathology
Genital Neoplasms, Female - radiotherapy
Genital Neoplasms, Female - surgery
Humans
Intraoperative Period
Intraoperative radiation therapy
Middle Aged
Primary disease
Prognosis
Recurrent disease
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Summary:The prognosis in women with locally advanced primary or recurrent gynecologic malignancies is rather poor. Doses of external beam radiation necessary to treat gross or microscopic recurrence among patients surgically treated or previously irradiated exceed what is tolerated by normal structures. In this group of patients, intraoperative radiation therapy (IORT) can be utilized to maximize local tumor control, minimizing the radiation exposure of dose‐limiting surrounding structures. Review of the available literature indicates that IORT may improve long‐term local control and overall survival in women with pelvic sidewall and/or para‐aortic nodal recurrence. The most encouraging results have been reported in the cases of microscopic residual disease, following surgical debulking.
ISSN:1083-7159
1549-490X
DOI:10.1634/theoncologist.5-1-18