Peripheral Blood T-Lymphocyte and Monocyte Function and Survival in Patients With Head and Neck Carcinoma

Objectives/Hypothesis To determine if the T‐lymphocyte and monocyte functions of peripheral blood mononuclear cells (PBMCs) from patients with head and neck squamous cell carcinomas (HNSCC) are predictive factors for outcome. Study Design A prospective study describing the outcome, as to total survi...

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Bibliographic Details
Published in:The Laryngoscope 2000-03, Vol.110 (3), p.402-407
Main Authors: Heimdal, John H., Aarstad, Hans J., Olofsson, Jan
Format: Article
Language:English
Subjects:
Aged
Alcohol Drinking - blood
Biological and medical sciences
Blood Proteins - analysis
Carcinoma, Squamous Cell - blood
Cell Division - drug effects
Cell Survival - physiology
Cells, Cultured
Follow-Up Studies
Forecasting
Head and Neck Neoplasms - blood
Hormones - blood
Humans
Interleukins - analysis
Lymphocyte Activation - drug effects
lymphocytes
Male
Medical sciences
Mitogens - pharmacology
monocytes
Monocytes - physiology
Neoplasm Staging
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Proportional Hazards Models
Prospective Studies
Regression Analysis
Smoking - blood
squamous cell carcinoma
Survival Analysis
Survival Rate
T-Lymphocytes - drug effects
T-Lymphocytes - physiology
TNM stage
Tumor Necrosis Factor-alpha - analysis
Tumors
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Summary:Objectives/Hypothesis To determine if the T‐lymphocyte and monocyte functions of peripheral blood mononuclear cells (PBMCs) from patients with head and neck squamous cell carcinomas (HNSCC) are predictive factors for outcome. Study Design A prospective study describing the outcome, as to total survival and death by disease after at least 40 months observation, of 81 previously untreated male HNSCC patients in relation to PBMC T‐lymphocyte and monocyte function. Methods T‐lymphocyte mitogenesis and the cytokine level in culture supernatants of PBMC as well as monocytes were analyzed. These parameters were related to survival by Cox regression and Kaplan‐Meier survival analysis. Results When patients with high versus low T‐lymphocyte mitogen–stimulated proliferations were compared, a decreased proliferation was seen to be related to worse outcome. The predictive value of T‐lymphocyte proliferation was shown to be an independent prognostic factor when adjusted for stage and stratified for anatomic location in survival analysis. The predictive value was also retained when the serum values of the major serum proteins and hormones and scores based on the smoking and alcohol history were added to the survival analysis with lymphocyte proliferation. Supernatant levels of γ‐interferon, interleukin (IL)‐2, or IL‐4 in PBMC cultures were not related to outcome. Monocyte function measured by endotoxin‐stimulated IL‐1β, IL‐6, IL‐12, and tumor necrosis factor‐α secretion did not relate to outcome of the patients. Conclusion The PBMC T‐lymphocyte–stimulated proliferation is an independent prognostic factor for male HNSCC patients.
ISSN:0023-852X
1531-4995
DOI:10.1097/00005537-200003000-00013