Notch signaling in T cell development

Notch signaling regulates cell fate decisions during development. Recent experiments suggest that Notch signaling is essential for initial commitment to the T cell lineage and may function together with signals from the pre-TCR and the TCR to regulate subsequent steps of T cell development.

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Bibliographic Details
Published in:Current Opinion in Immunology 2000-04, Vol.12 (2), p.166-172
Main Authors: Deftos, Michael L, Bevan, Michael J
Format: Article
Language:English
Subjects:
AIDS/HIV
Alpha-beta T cell development
Animals
CD4-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - cytology
Cell Differentiation
Cell Lineage
Feedback
Gamma-delta T cell development
Gene Expression Regulation, Developmental
Hematopoiesis - genetics
Hematopoietic Stem Cells - cytology
Humans
Lineage commitment
Membrane Proteins - genetics
Membrane Proteins - physiology
Mice
Mice, Knockout
Notch
Notch protein
Proto-Oncogene Proteins - genetics
Proto-Oncogene Proteins - physiology
Receptor, Notch1
Receptor, Notch2
Receptor, Notch4
Receptors, Antigen, T-Cell - genetics
Receptors, Cell Surface - genetics
Receptors, Cell Surface - physiology
Receptors, Notch
Signal Transduction
T-Lymphocyte Subsets - cytology
Thymocyte development
Thymus Gland - cytology
Transcription Factors - classification
Transcription Factors - physiology
Transcription, Genetic
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Description
Summary:Notch signaling regulates cell fate decisions during development. Recent experiments suggest that Notch signaling is essential for initial commitment to the T cell lineage and may function together with signals from the pre-TCR and the TCR to regulate subsequent steps of T cell development.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(99)00067-9