The sensitivity and specificity of FDG PET in distinguishing recurrent brain tumor from radionecrosis in patients treated with stereotactic radiosurgery

Radiation necrosis and recurrent brain tumor have similar symptoms and are indistinguishable on both magnetic resonance imaging (MRI) and computed tomograph scans. 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) has been proposed as a diagnostic alternative, particularly when co‐regi...

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Bibliographic Details
Published in:International journal of cancer 2001-06, Vol.96 (3), p.191-197
Main Authors: Chao, Samuel T., Suh, John H., Raja, Shanker, Lee, Shih‐Yuan, Barnett, Gene
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Brain Neoplasms - surgery
brain tumor
Child
Diagnosis, Differential
Diseases of the nervous system
Female
Fluorodeoxyglucose F18
Humans
Male
Medical sciences
Middle Aged
Necrosis
positron emission tomography
Radiography
radionecrosis
Radiosurgery
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Recurrence
Sensitivity and Specificity
stereotactic radiosurgery
Tomography, Emission-Computed
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Summary:Radiation necrosis and recurrent brain tumor have similar symptoms and are indistinguishable on both magnetic resonance imaging (MRI) and computed tomograph scans. 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET) has been proposed as a diagnostic alternative, particularly when co‐registered with MRI. We studied 47 patients with brain tumors treated with stereotactic radiosurgery and followed with FDG PET. For all tumor types, the sensitivity of FDG PET for diagnosing tumor was 75% and the specificity was 81%. For brain metastasis without MRI co‐registration, FDG PET had a sensitivity of 65% and a specificity of 80%. For brain metastasis with MRI co‐registration, FDG PET had a sensitivity of 86% and specificity of 80%. MRI co‐registration appears to improve the sensitivity of FDG PET, making it a useful modality to distinguish between radiation necrosis and recurrent brain metastasis. © 2001 Wiley‐Liss, Inc.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.1016