Correlation of genotypes and route of transmission with histologic activity and disease stage in chronic hepatitis C

Our objective was to evaluate the histopathological features of chronic hepatitis C of 64 liver biopsies and to correlate this with the route of transmission of hepatitis C virus, the genotype of HCV, and the patient's age. Moderate chronic hepatitis was the most frequently observed (62.5%). Ci...

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Published in:Digestive diseases and sciences 2000, Vol.45 (1), p.182-187
Main Authors: RAMALHO, F, COSTA, A, MARINHO, R, RAIMUNDO, M, VELOSA, J, BATISTA, A, DE MOURA, M. C, PIRES, A, CABRITA, P, SEREJO, F, CORREIA, A. P, FATELA, N, CLORIA, H, LOPES, J, PINTO, H. C
Format: Article
Language:English
Subjects:
Adult
Age Factors
Bacterial diseases
Bacterial diseases of the urinary system
Biological and medical sciences
Case-Control Studies
Female
Genotype
Hepacivirus - genetics
Hepatitis C - transmission
Hepatitis C, Chronic - pathology
Hepatitis C, Chronic - virology
Human bacterial diseases
Humans
Infectious diseases
Liver - pathology
Male
Medical sciences
Middle Aged
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Summary:Our objective was to evaluate the histopathological features of chronic hepatitis C of 64 liver biopsies and to correlate this with the route of transmission of hepatitis C virus, the genotype of HCV, and the patient's age. Moderate chronic hepatitis was the most frequently observed (62.5%). Cirrhosis was observed in 14 patients (21.9%) and was more frequently found among patients over 40 years of age (34.3% vs. 6.9%, P = 0.025). The mean histopathological activity index (HAI) was significantly higher in the sporadic (10+/-3.1) than the posttransfusional (7.5+/-3.7) and the intravenous drug use (IVDU) groups (6.3+/-2.8) (P
ISSN:0163-2116
1573-2568
DOI:10.1023/A:1005442317680