Eccentric exercise-induced injuries to contractile and cytoskeletal muscle fibre components

Exercise involving lengthening of an activated muscle can cause injury. Recent reports documented the mechanics of exercise‐induced muscle injury as well as physiological and cellular events and manifestations of injury. Loss of the cytoskeletal protein desmin and loss of cellular integrity as evide...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 2001-03, Vol.171 (3), p.321-326
Main Authors: Fridén, J., Lieber, R. L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
cytoskeleton
Cytoskeleton - metabolism
Cytoskeleton - pathology
delayed-onset muscle soreness
Desmin - metabolism
Diseases of striated muscles. Neuromuscular diseases
Exercise
Humans
Medical sciences
Muscle Contraction
Muscle Fibers, Skeletal - metabolism
Muscle Fibers, Skeletal - pathology
muscle injury
muscle morphology
muscle strength
Muscle Weakness - metabolism
Muscle, Skeletal - injuries
Muscle, Skeletal - metabolism
Muscle, Skeletal - pathology
Neurology
Sarcolemma - pathology
Stress, Mechanical
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Summary:Exercise involving lengthening of an activated muscle can cause injury. Recent reports documented the mechanics of exercise‐induced muscle injury as well as physiological and cellular events and manifestations of injury. Loss of the cytoskeletal protein desmin and loss of cellular integrity as evidenced by sarcolemmal damage occur early during heavy eccentric exercise. These studies indicate that the earliest events in muscle injury are mechanical in nature, while later events indicate that it may be more appropriate to conclude that intense exercise initiates a muscle remodeling process. We conclude that muscle injury after eccentric exercise is differently severe in muscles with different architecture, is fibre type‐specific, primarily because of fibre strain in the acute phase, and is exacerbated by inflammation after the initial injury.
ISSN:0001-6772
1365-201X
DOI:10.1046/j.1365-201x.2001.00834.x