Nerve growth factor and neurotrophin-3 promote chemotaxis of mouse macrophages in vitro

Microchemotaxis chambers were used to explore macrophage chemotaxis in response to the neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Both NGF and NT-3, but not BDNF, promoted macrophage chemotaxis that was receptor mediated and dependen...

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Bibliographic Details
Published in:Neuroscience letters 2001-06, Vol.305 (3), p.157-160
Main Authors: KOBAYASHI, H, MIZISIN, A. P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain-Derived Neurotrophic Factor - pharmacology
Cell physiology
Cells, Cultured
Chemotaxis - drug effects
Female
Fundamental and applied biological sciences. Psychology
Macrophages - drug effects
Macrophages - physiology
Mice
Molecular and cellular biology
Nerve Growth Factor - pharmacology
Neurotrophin 3 - pharmacology
Responses to growth factors, tumor promotors, other factors
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Summary:Microchemotaxis chambers were used to explore macrophage chemotaxis in response to the neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Both NGF and NT-3, but not BDNF, promoted macrophage chemotaxis that was receptor mediated and dependent on protein phosphorylation. These in vitro observations point to novel roles for neurotrophins that are present in nerve prior to and immediately after injury.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(01)01854-7