Helper T cell differentiation, inside and out

The past year has seen remarkable progress in the field of helper T cell differentiation, including discovery of a novel transcription factor as well as a novel cytokine receptor of the Th1 lineage. The year has also brought new perspectives on the genetic and epigenetic control of gene expression....

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Bibliographic Details
Published in:Current Opinion in Immunology 2001-06, Vol.13 (3), p.351-355
Main Author: Reiner, Steven L
Format: Article
Language:English
Subjects:
Animals
cell cycle
Cell Cycle - immunology
Cell Differentiation - immunology
chromatin
cytokine
cytokine receptors
epigenetic
Gata-3
Humans
methylation
repression
silencing
T cell
T-bet
Th1 Cells - cytology
Th1 Cells - immunology
Th2 Cells - cytology
Th2 Cells - immunology
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Summary:The past year has seen remarkable progress in the field of helper T cell differentiation, including discovery of a novel transcription factor as well as a novel cytokine receptor of the Th1 lineage. The year has also brought new perspectives on the genetic and epigenetic control of gene expression. It is likely that mechanisms of immunity will continue to provide insight into the general problem of cellular decision-making.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(00)00226-0