Activated protein C and inflammation in human myocardium after heart surgery

To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post‐ischemic reperfusion protein C, APC, neutrophil L‐selectin expression and myocardial myeloperoxidase activity (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. Af...

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Bibliographic Details
Published in:American journal of hematology 2001-07, Vol.67 (3), p.210-212
Main Authors: Petäjä, Jari, Pesonen, Eero, Fernández, José A., Griffin, John H., Repo, Heikki, Jansson, Sten‐Erik, Vento, Antti E., Rämö, O. Juhani
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Cardiopulmonary Bypass - adverse effects
coronary reperfusion
Enzyme Activation
granulocyte
Heart Arrest, Induced - adverse effects
heart surgery
Humans
L-Selectin - analysis
Male
Medical sciences
Middle Aged
Myocardial Reperfusion Injury - blood
Myocardial Reperfusion Injury - etiology
Myocarditis - etiology
Neutrophils - enzymology
Peroxidase - analysis
protein C
Protein C - analysis
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
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Summary:To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post‐ischemic reperfusion protein C, APC, neutrophil L‐selectin expression and myocardial myeloperoxidase activity (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. After reperfusion for 10 min, APC to protein C ratio (APC/PC) increased from pre‐reperfusion value 1.43 ± 0.12 (mean ± SEM) to 2.25 ± 0.29, p = 0.015. Negative correlations were observed between APC/PC and MPO activity (Spearman r −0.64, p = 0.007) and APC/PC and neutrophil L‐selectin expression (r = −0.7, p = 0.007, demonstrating that post‐ishemic protein C activation was associated with decreased neutrophil tissue sequestration. Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation. Am. J. Hematol. 67:210–212, 2001. © 2001 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.1110