Vibrio cholerae Resistant to 2,4-diamino-6, 7-diisopropylpteridine (O/129) Isolated from Patients with Enteritis in Ceará, Brazil

This paper reports the characterization of clinical Vibrio cholerae resistant to vibriostatic agent O/129, using classical and plasmid analysis. In a study conducted during December 1991-September 1993, two of 7,058 V. cholerae strains, obtained from patients suspected to have cholera in the State o...

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Bibliographic Details
Published in:Journal of health, population and nutrition population and nutrition, 2001-03, Vol.19 (1), p.39-42
Main Authors: Hofer, Ernesto, Reis, E.M.F., Quintaes, B.R., Rodrigues, D.P., Feitosa, I.S., Angelo, M.R.F., Ribeiro, L.H.F.F.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antimicrobials
Brazil
Cholera
Cholera - microbiology
Drug resistance
Drug resistance in microorganisms
Drug Resistance, Microbial
Enteritis
Enteritis - microbiology
Feces - microbiology
Genetic aspects
Health aspects
Humans
Microbiology
Plasmids
Pteridines - pharmacology
SHORT REPORT
Studies
Vibrio
Vibrio cholerae
Vibrio cholerae - drug effects
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Summary:This paper reports the characterization of clinical Vibrio cholerae resistant to vibriostatic agent O/129, using classical and plasmid analysis. In a study conducted during December 1991-September 1993, two of 7,058 V. cholerae strains, obtained from patients suspected to have cholera in the State of Ceará, northeast Brazil, were resistant to 150 μg of the vibriostatic agent O/129 (2,4-diamino-6,7-diisopropylpteridine). One strain was identified as V. cholerae O1 El Tor Inaba and the other one as serogroup O22. Only one O1 strain harboured a plasmid of 147 kb transferable to Escherichia coli K12, and five strains of V. cholerae O1 and non-O1 were sensitive to O/129 and plasmid-negative at a frequency between 8×10-2 and 3.6×10-5. Additionally, O/129-resistant strains of V. cholerae O1 and O22 were resistant to trimethoprim/sulphamethoxazole.
ISSN:1606-0997
2072-1315