Anxiolytic-like actions of melatonin, 5-metoxytryptophol, 5-hydroxytryptophol and benzodiazepines on a conflict procedure

1. 1. Male Wistar rats (120–230 g) were used in these experiments. Some rats were deprived of water for 48 h before testing in a conflict procedure. Then, after 20 licks from a water bottle with a metal drinking tube, the animal received an electric shock (0.5 mA/500 msec). 2. 2. The effects of two...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2000, Vol.24 (1), p.117-129
Main Authors: Naranjo-rodriguez, Elia B., Osornio, Alejandro Ortiz, Hernandezavttia, Eva, Mendozafernandez, Victor, Escobar, Alfonso
Format: Article
Language:English
Subjects:
5-hydroxytryptophol
5-metoxytryptophol
Animals
Anti-Anxiety Agents - pharmacology
anxiolytic
benzodiazepines
Biological and medical sciences
conflict
Conflict (Psychology)
Diazepam - pharmacology
Dose-Response Relationship, Drug
Electroshock
Emotional behavior
Hydroxytryptophol - pharmacology
Indoles - pharmacology
Injections, Intraperitoneal
Male
Medical sciences
melatonin
Melatonin - pharmacology
Neuropharmacology
Pharmacology. Drug treatments
Psycholeptics: tranquillizer, neuroleptic
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Rats
Rats, Wistar
stress
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Summary:1. 1. Male Wistar rats (120–230 g) were used in these experiments. Some rats were deprived of water for 48 h before testing in a conflict procedure. Then, after 20 licks from a water bottle with a metal drinking tube, the animal received an electric shock (0.5 mA/500 msec). 2. 2. The effects of two classical anxiolytic drugs, DIAZ (1.0, 2.0 and 4.0 mg/Kg b.wt), and CDP (5.0 and 10.0 mg/Kg b.wt) were compared to those produced by MEL (0.1, 0.2, 0.5, 1.0 and 2.0 mg/Kg b.wt), 5-MTOPHOL (1.0 and 2.0 mg/Kg b.wt), 5-HTOPHOL (1.0 and 2.0 mg/Kg b.wt) and vehicle solution. 3. 3. Anxiolytic drugs as well as MEL produced a dose-dependent increase in the number of shocks received. 4. 4. The results suggest that the three pineal indoles are involved in the modulation of the stress responses. MEL showed a higher potency than the other indoles.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(99)00075-5