Impact of Respiratory Virus Infections on Persons With Chronic Underlying Conditions

CONTEXT While hospitalization rates have declined overall, hospitalizations for acute lower respiratory tract infections have increased steadily since 1980. Development of new approaches for prevention of acute respiratory tract conditions requires studies of the etiologies of infections and quantif...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2000-01, Vol.283 (4), p.499-505
Main Authors: Glezen, W. Paul, Greenberg, Stephen B, Atmar, Robert L, Piedra, Pedro A, Couch, Robert B
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Biological and medical sciences
Child
Child, Preschool
Chronic Disease
Disease Susceptibility
Hospitalization
Hospitalization - statistics & numerical data
Human viral diseases
Humans
Infant
Infections
Infectious diseases
Influenza, Human - epidemiology
Medical sciences
Middle Aged
Paramyxoviridae Infections - epidemiology
Respiratory diseases
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Risk Factors
Socioeconomic Factors
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viruses
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Summary:CONTEXT While hospitalization rates have declined overall, hospitalizations for acute lower respiratory tract infections have increased steadily since 1980. Development of new approaches for prevention of acute respiratory tract conditions requires studies of the etiologies of infections and quantification of the risk of hospitalization for vulnerable patients. OBJECTIVE To determine the frequency of specific virus infections associated with acute respiratory tract conditions leading to hospitalization of chronically ill patients. DESIGN Analysis of viral etiology of patients hospitalized with acute respiratory tract conditions between July 1991 and June 1995. SETTING Four large clinics and related hospitals serving diverse populations representative of Harris County, Texas. PATIENTS A total of 1029 patients who were hospitalized for pneumonia, tracheobronchitis, bronchiolitis, croup, exacerbations of asthma or chronic obstructive pulmonary disease, and/or congestive heart failure. MAIN OUTCOME MEASURE Virus infection, defined by culture, antigen detection, and significant rise in serum antibodies, by underlying condition; hospitalization rates by low- vs middle-income status. RESULTS Ninety-three percent of patients older than 5 years had a chronic underlying condition; a chronic pulmonary condition was most common. Patients with chronic pulmonary disease from low-income populations were hospitalized at a rate of 398.6 per 10,000, almost 8 times higher than the rate for patients from middle-income groups (52.2 per 10,000; P
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.283.4.499