A morphometric MRI study of the hippocampus in first-episode, neuroleptic-naïve schizophrenia

Magnetic resonance imaging (MRI) studies have frequently, although not unambiguously, reported hippocampal volume deficit in schizophrenia. Data on the hippocampal volumes in first-episode schizophrenia, however, are sparse. In addition, a recent topographic MRI study proposed a regionally specific...

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Bibliographic Details
Published in:Schizophrenia research 2001-05, Vol.50 (1-2), p.3-7
Main Authors: LAAKSO, M. P, TIIHONEN, J, SYVÄLAHTI, E, VILKMAN, H, LAAKSO, A, ALAKARE, B, RÄKKÖLÄINEN, V, SALOKANGAS, R. K. R, KOIVISTO, E, HIETALA, J
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antipsychotic Agents - therapeutic use
Biological and medical sciences
Female
Functional Laterality - physiology
Hippocampus - abnormalities
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - drug therapy
Temporal Lobe - anatomy & histology
Time Factors
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Summary:Magnetic resonance imaging (MRI) studies have frequently, although not unambiguously, reported hippocampal volume deficit in schizophrenia. Data on the hippocampal volumes in first-episode schizophrenia, however, are sparse. In addition, a recent topographic MRI study proposed a regionally specific volume loss in the hippocampus of chronic schizophrenics, but to date no reports have replicated this finding. In this study two-dimensional MRI-based topographic brain mapping was used to study the possibility of regional changes in the hippocampus of 22 controls and 18 patients with first-episode, neuroleptic-naïve schizophrenia. Compared to controls, there were no significant differences between hippocampal volumes, regional volumes, or length of the hippocampus in the patients with schizophrenia. These data are at odds with the previous reports on hippocampal volume loss in first-episode schizophrenia, and with the hypothesis of regionally specific hippocampal volume deficit in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/S0920-9964(00)00155-9