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Discovery of Orally Active Nonpeptide Vitronectin Receptor Antagonists Based on a 2-Benzazepine Gly-Asp Mimetic

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Bibliographic Details
Published in:	Journal of medicinal chemistry 2000-01, Vol.43 (1), p.22-26
Main Authors:	Miller, William H, Alberts, Doreen P, Bhatnagar, Pradip K, Bondinell, William E, Callahan, James F, Calvo, Raul R, Cousins, Russell D, Erhard, Karl F, Heerding, Dirk A, Keenan, Richard M, Kwon, Chet, Manley, Peter J, Newlander, Kenneth A, Ross, Stephen T, Samanen, James M, Uzinskas, Irene N, Venslavsky, Joseph W, Yuan, Catherine C.-K, Haltiwanger, R. Curtis, Gowen, Maxine, Hwang, Shing-Mei, James, Ian E, Lark, Michael W, Rieman, David J, Stroup, George B, Azzarano, Leonard M, Salyers, Kevin L, Smith, Brian R, Ward, Keith W, Johanson, Kyung O, Huffman, William F
Format:	Article
Language:	English
Subjects:	Animals Benzazepines - chemical synthesis Benzazepines - pharmacokinetics Benzazepines - pharmacology Biological and medical sciences Biological Availability Bone Resorption - prevention & control Bones, joints and connective tissue. Antiinflammatory agents Cell Adhesion - drug effects Cell Line Half-Life Humans Medical sciences Molecular Mimicry Osteoclasts - drug effects Osteoclasts - metabolism Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - pharmacokinetics Pyridines - pharmacology Rats Receptors, Vitronectin - antagonists & inhibitors Stereoisomerism Tissue Distribution
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