Membrane Skeleton Detachment in Spherical and Cylindrical Microexovesicles

We observed that amphiphile-induced microexovesicles may be spherical or cylindrical, depending on the species of the added amphiphile. The spherical microexovesicle corresponds to an extreme local difference between the two monolayer areas of the membrane segment with a fixed area, while the cylind...

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Bibliographic Details
Published in:Bulletin of mathematical biology 1999-11, Vol.61 (6), p.1019-1030
Main Author: HAGERSTRAND, H
Format: Article
Language:English
Subjects:
Algorithms
Anion Exchange Protein 1, Erythrocyte - analysis
Detergents - pharmacology
Elasticity
Erythrocyte Membrane - chemistry
Erythrocyte Membrane - drug effects
Erythrocyte Membrane - ultrastructure
Erythrocytes - chemistry
Erythrocytes - drug effects
Erythrocytes - ultrastructure
Glucosides - pharmacology
Humans
Microscopy, Electron
Models, Biological
Quaternary Ammonium Compounds - pharmacology
Spectrin - analysis
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Summary:We observed that amphiphile-induced microexovesicles may be spherical or cylindrical, depending on the species of the added amphiphile. The spherical microexovesicle corresponds to an extreme local difference between the two monolayer areas of the membrane segment with a fixed area, while the cylindrical microexovesicle corresponds to an extreme local area difference if the area of the budding segment is increased due to lateral influx of anisotropic membrane constituents. Protein analysis showed that both types of vesicles are highly depleted in the membrane skeleton. It is suggested that a partial detachment of the skeleton in the budding region is favoured due to accumulated skeleton shear deformations in this region.
ISSN:0092-8240
1522-9602
DOI:10.1006/bulm.1999.0128