Effect of vaccination on the potentiation of porcine reproductive and respiratory syndrome virus (PRRSV)-induced pneumonia by Mycoplasma hyopneumoniae

Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae are frequently isolated pathogens from pigs with respiratory disease. A previous study conducted in our laboratory found that infection with M. hyopneumoniae increased the duration and severity of respiratory di...

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Bibliographic Details
Published in:Vaccine 2000-01, Vol.18 (13), p.1244-1252
Main Authors: Thacker, Eileen L., Thacker, Brad J., Young, Theresa F., Halbur, Patrick G.
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - biosynthesis
Antibodies, Bacterial - blood
Antibody Specificity
Bacterial Vaccines - immunology
Bacterial Vaccines - therapeutic use
Biological and medical sciences
Bronchoalveolar Lavage Fluid - immunology
Experimental viral diseases and models
Immunoglobulin G - biosynthesis
Immunoglobulin G - blood
Infectious diseases
Lung - immunology
Lung - microbiology
Lung - pathology
Lung - virology
Medical sciences
Mycoplasma - immunology
Mycoplasma - isolation & purification
Mycoplasma hyopneumoniae
Pneumonia of Swine, Mycoplasmal - immunology
Pneumonia of Swine, Mycoplasmal - prevention & control
Pneumonia of Swine, Mycoplasmal - veterinary
Pneumonia, Viral - immunology
Pneumonia, Viral - veterinary
Porcine Reproductive and Respiratory Syndrome - immunology
Porcine Reproductive and Respiratory Syndrome - microbiology
Porcine Reproductive and Respiratory Syndrome - prevention & control
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - immunology
Porcine respiratory and reproductive syndrome virus - isolation & purification
PRRSV
Random Allocation
Swine
Swine Diseases - immunology
Swine Diseases - microbiology
Swine Diseases - prevention & control
Vaccination
Viral diseases
Viral Vaccines - immunology
Viral Vaccines - therapeutic use
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Summary:Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae are frequently isolated pathogens from pigs with respiratory disease. A previous study conducted in our laboratory found that infection with M. hyopneumoniae increased the duration and severity of respiratory disease induced by PRRSV. The purpose of this experiment was to determine whether vaccination against M. hyopneumoniae and/or PRRSV decreased the enhancement of PRRSV-induced pneumonia. Both M. hyopneumoniae bacterin and PRRSV vaccine decreased the severity of clinical respiratory disease. Infection or vaccination with PRRSV appeared to decrease the efficacy of the M. hyopneumoniae bacterin. Vaccination with M. hyopneumoniae bacterin decreased the potentiation of PRRSV-induced pneumonia observed in the dual infected pigs. However, PRRSV vaccination in combination with M. hyopneumoniae bacterin eliminated this benefit and the amount of pneumonia induced by PRRSV increased. PRRSV vaccine alone did not decrease the potentiation of PRRSV pneumonia by M. hyopneumoniae.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(99)00395-3