Levofloxacin in vitro activity and time-kill evaluation of Stenotrophomonas maltophilia clinical isolates

The in vitro activity of levofloxacin and eight other antimicrobial agents against 60 clinical isolates of Stenotrophomonas maltophilia was determined by an agar dilution method using 10(4) and 10(6) cfu/spot inocula. At the lower inoculum, 85.0% of the isolates were susceptible to levofloxacin but...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2000, Vol.45 (1), p.115-117
Main Authors: BONFIGLIO, G, CASCONE, C, AZZARELLI, C, CAFISO, V, MARCHETTI, F, STEFANI, S
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Humans
Levofloxacin
Medical sciences
Microbial Sensitivity Tests
Ofloxacin - pharmacology
Pharmacology. Drug treatments
Stenotrophomonas maltophilia
Stenotrophomonas maltophilia - drug effects
Time Factors
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Summary:The in vitro activity of levofloxacin and eight other antimicrobial agents against 60 clinical isolates of Stenotrophomonas maltophilia was determined by an agar dilution method using 10(4) and 10(6) cfu/spot inocula. At the lower inoculum, 85.0% of the isolates were susceptible to levofloxacin but only 58.3% were susceptible to ofloxacin; at the higher inoculum, 78.3% were susceptible to levofloxacin and 36.7% to ofloxacin. In time-kill studies, levofloxacin exerted bactericidal activity within 4 h. With ofloxacin and ciprofloxacin bacterial regrowth was observed after 8 h. Levofloxacin may represent an alternative drug in the treatment of infections caused by S. maltophilia.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/45.1.115