Immune reconstitution after transplantation of autologous peripheral CD34+ cells: analysis of predictive factors and comparison with unselected progenitor transplants

The recovery of lymphocyte count, CD4+ and CD8+ T‐cell subsets, natural killer (NK) cells and CD19+ B‐cells was evaluated in a cohort of 15 patients receiving autologous CD34+ peripheral blood progenitor cells (PBPCs; group A) for haematological malignancies and in 20 patients transplanted with auto...

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Bibliographic Details
Published in:British journal of haematology 2000-01, Vol.108 (1), p.105-115
Main Authors: Rutella, Sergio, Rumi, Carlo, Laurenti, Luca, Pierelli, Luca, Sora', Federica, Sica, Simona, Leone, Giuseppe
Format: Article
Language:English
Subjects:
Adult
AIDS/HIV
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Antigens, CD34 - immunology
autologous selected CD34+ cells
Biological and medical sciences
Bone marrow, stem cells transplantation. Graft versus host reaction
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Female
flow cytometry
Graft Survival
Granulocyte Colony-Stimulating Factor - therapeutic use
granulocyte colony‐stimulating factor
Hematology
Hematopoietic Stem Cell Transplantation - methods
Hodgkin Disease - immunology
Hodgkin Disease - therapy
Humans
immune reconstitution
Lymphocyte Count
Lymphoma, Non-Hodgkin - immunology
Lymphoma, Non-Hodgkin - therapy
Male
Medical sciences
Middle Aged
Multiple Myeloma - immunology
Multiple Myeloma - therapy
predictive factors
T-Lymphocyte Subsets - immunology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Transplantation Immunology
Transplantation, Autologous
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Summary:The recovery of lymphocyte count, CD4+ and CD8+ T‐cell subsets, natural killer (NK) cells and CD19+ B‐cells was evaluated in a cohort of 15 patients receiving autologous CD34+ peripheral blood progenitor cells (PBPCs; group A) for haematological malignancies and in 20 patients transplanted with autologous unselected PBPCs (group B). Lymphocyte count recovered in both patient cohorts, being significantly lower in group A than in group B 1 (P = 0·008) and 2 months (P = 0·0035) after progenitor cell infusion. The repopulation of CD3+ T‐cells occurred more rapidly in group B than in group A (P = 0·034 on week 4); CD19+ B‐lymphocytes did not return to reference ranges in either group of patients. The count of CD4+ T‐lymphocytes remained  0·5 × 109/l (r = –0·63, P = 0·01). Further investigations are necessary to characterize T‐cell competence after transplantation of CD34+ PBPCs.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2000.01824.x