Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study

Utilisation of enamel matrix proteins (EMD) and application of the guided tissue regeneration principle (GTR) are treatment modalities which both have been shown to result in periodontal regeneration. However, it is yet unknown whether the combination of EMD and GTR may additionally favor the regene...

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Bibliographic Details
Published in:Journal of clinical periodontology 2001-05, Vol.28 (5), p.397-403
Main Authors: Sculean, A, Windisch, P, Chiantella, G C, Donos, N, Brecx, M, Reich, E
Format: Article
Language:English
Subjects:
Adult
Aged
Alveolar Bone Loss - surgery
Bone Substitutes - therapeutic use
Combined Modality Therapy
Dental Enamel Proteins - therapeutic use
Dental Plaque Index
Dentistry
Female
Follow-Up Studies
Gingival Hemorrhage - surgery
Gingival Recession - surgery
Guided Tissue Regeneration, Periodontal - methods
Humans
Male
Middle Aged
Periodontal Attachment Loss - surgery
Periodontal Index
Periodontal Pocket - surgery
Prospective Studies
Single-Blind Method
Statistics as Topic
Surgical Flaps
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Summary:Utilisation of enamel matrix proteins (EMD) and application of the guided tissue regeneration principle (GTR) are treatment modalities which both have been shown to result in periodontal regeneration. However, it is yet unknown whether the combination of EMD and GTR may additionally favor the regeneration process. The aim of the present controlled study was to evaluate clinically the treatment effect of EMD, GTR, combination of EMD and GTR, and flap surgery (control) on intrabony defects. 56 patients each of whom displaying one intrabony defect of a depth of at least 6 mm were randomly treated with one of the treatment modalities. Prior to surgery and at one year after, the following parameters were evaluated by a blinded examiner: Plaque index (PlI), gingival index (GI), bleeding on probing (BOP), probing pocket depth (PPD), gingival recession (GR) and clinical attachment level (CAL). No statistical significant differences between the four groups were observed at baseline for any of the investigated parameters. At 1 year after therapy, the sites treated with EMD demonstrated a mean PPD reduction of 4.1 +/- 1.7 mm and a mean CAL gain of 3.4 +/- 1.5 mm (p
ISSN:0303-6979
1600-051X
DOI:10.1034/j.1600-051x.2001.028005397.x