Remitting seronegative symmetrical synovitis with pitting oedema in a patient with myelodysplastic syndrome and relapsing polychondritis

Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) may be the inaugural manifestation of different rheumatic diseases of the elderly, malignancies and myelodysplastic syndromes (MDS). Relapsing polychondritis (RP) is a rare systemic disorder characterised by an inflammatory pro...

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Bibliographic Details
Published in:Clinical rheumatology 2001-01, Vol.20 (2), p.132-135
Main Authors: Manganelli, P, Delsante, G, Bianchi, G, Fietta, P, Quaini, F
Format: Article
Language:English
Subjects:
Aged
Edema - etiology
Edema - pathology
Fatal Outcome
Humans
Male
Medical disorders
Medical treatment
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - pathology
Polychondritis, Relapsing - complications
Polychondritis, Relapsing - pathology
Rheumatic diseases
Rheumatoid Factor - blood
Synovitis - blood
Synovitis - etiology
Synovitis - pathology
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Summary:Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) may be the inaugural manifestation of different rheumatic diseases of the elderly, malignancies and myelodysplastic syndromes (MDS). Relapsing polychondritis (RP) is a rare systemic disorder characterised by an inflammatory process involving predominantly cartilaginous structures, the cardiovascular system and organs of special sense. We report on a 72-year-old man with RS3PE and MDS, refractory anaemia subtype, diagnosed at the same time as RS3PE. Several months later the patient presented a clinical and pathological picture compatible with RP. Although the association between RP and MDS is well known, no previous cases of RS3PE preceding RP have been reported. This case confirms that RS3PE may herald many diseases, among others autoimmune disorders such as RP.
ISSN:0770-3198
1434-9949
DOI:10.1007/PL00011192