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Changes in Fructose-Induced Production of Glucose in the Rat Liver Following Partial Hepatectomy
The fructose-induced production of glucose in the liver after partial hepatectomy (PH) was evaluated by using the liver-perfusion system. There was no significant difference in plasma glucose level between hepatectomized (HX) and sham-operated (SO) rats at 24 h after surgery, and, thereafter, almost...
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| Published in: | Archives of biochemistry and biophysics 1999-11, Vol.371 (1), p.53-62 |
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| container_end_page | 62 |
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| container_title | Archives of biochemistry and biophysics |
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| creator | Moriyama, Mitsuaki Nishisako, Mototaka Ueda, Junko Kannan, Yukiko Ohta, Mitsuaki Sugano, Tsukasa |
| description | The fructose-induced production of glucose in the liver after partial hepatectomy (PH) was evaluated by using the liver-perfusion system. There was no significant difference in plasma glucose level between hepatectomized (HX) and sham-operated (SO) rats at 24 h after surgery, and, thereafter, almost similar levels were obtained in both groups. However, the level of serum free fatty acids (FFA) was significantly higher in HX rats than that in SO rats at 24 and 48 h after surgery. When both groups of rats were given fructose by gavage, the increment of plasma glucose was significantly larger in HX rats than in SO rats. Lactate infusion failed to increase the rate of glucose production in perfused livers of both HX and SO rats and there was no significant difference in the activity of hepatic phosphoenolpyruvate carboxykinase. By contrast, fructose infusion elicited a large increase in glucose production in the perfused livers of HX rats at 24 and 48 h after PH. The increase was closely associated with not the change in fructose 2,6-bisphosphate levels but the increment of the intracellular levels of citrate. Treatment of octanoate or oleate, which supplies acetyl-CoA via fatty acid oxidation, mimicked the fructose-induced increase in glucose production in SO rats with a concomitant increase in hepatic levels of citrate. These results suggest that the oxidation of FFA may play an important role in glucose production induced by fructose administration during the early phase of liver regeneration. |
| doi_str_mv | 10.1006/abbi.1999.1422 |
| format | article |
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There was no significant difference in plasma glucose level between hepatectomized (HX) and sham-operated (SO) rats at 24 h after surgery, and, thereafter, almost similar levels were obtained in both groups. However, the level of serum free fatty acids (FFA) was significantly higher in HX rats than that in SO rats at 24 and 48 h after surgery. When both groups of rats were given fructose by gavage, the increment of plasma glucose was significantly larger in HX rats than in SO rats. Lactate infusion failed to increase the rate of glucose production in perfused livers of both HX and SO rats and there was no significant difference in the activity of hepatic phosphoenolpyruvate carboxykinase. By contrast, fructose infusion elicited a large increase in glucose production in the perfused livers of HX rats at 24 and 48 h after PH. The increase was closely associated with not the change in fructose 2,6-bisphosphate levels but the increment of the intracellular levels of citrate. Treatment of octanoate or oleate, which supplies acetyl-CoA via fatty acid oxidation, mimicked the fructose-induced increase in glucose production in SO rats with a concomitant increase in hepatic levels of citrate. These results suggest that the oxidation of FFA may play an important role in glucose production induced by fructose administration during the early phase of liver regeneration.</description><identifier>ISSN: 0003-9861</identifier><identifier>EISSN: 1096-0384</identifier><identifier>DOI: 10.1006/abbi.1999.1422</identifier><identifier>PMID: 10525289</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetyl Coenzyme A - metabolism ; acetyl-CoA ; Animals ; Blood Glucose - metabolism ; citrate ; Citrates - metabolism ; Energy Intake ; Fatty Acids, Nonesterified - blood ; free fatty acids ; fructose ; Fructose - metabolism ; fructose 2,6-bisphosphate ; Fructosephosphates - metabolism ; Gluconeogenesis ; glucose ; Glucose - metabolism ; Hepatectomy ; Kinetics ; Lactates - metabolism ; Liver - metabolism ; liver regeneration ; Liver Regeneration - physiology ; Male ; Phosphoenolpyruvate Carboxykinase (GTP) - metabolism ; Pyruvates - metabolism ; Rats ; Rats, Sprague-Dawley ; Reference Values</subject><ispartof>Archives of biochemistry and biophysics, 1999-11, Vol.371 (1), p.53-62</ispartof><rights>1999 Academic Press</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c319t-df15d8031bba37dd0d0a4156d4767effc8b1b62ae91029d1ffb0dbe9deb150093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10525289$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moriyama, Mitsuaki</creatorcontrib><creatorcontrib>Nishisako, Mototaka</creatorcontrib><creatorcontrib>Ueda, Junko</creatorcontrib><creatorcontrib>Kannan, Yukiko</creatorcontrib><creatorcontrib>Ohta, Mitsuaki</creatorcontrib><creatorcontrib>Sugano, Tsukasa</creatorcontrib><title>Changes in Fructose-Induced Production of Glucose in the Rat Liver Following Partial Hepatectomy</title><title>Archives of biochemistry and biophysics</title><addtitle>Arch Biochem Biophys</addtitle><description>The fructose-induced production of glucose in the liver after partial hepatectomy (PH) was evaluated by using the liver-perfusion system. There was no significant difference in plasma glucose level between hepatectomized (HX) and sham-operated (SO) rats at 24 h after surgery, and, thereafter, almost similar levels were obtained in both groups. However, the level of serum free fatty acids (FFA) was significantly higher in HX rats than that in SO rats at 24 and 48 h after surgery. When both groups of rats were given fructose by gavage, the increment of plasma glucose was significantly larger in HX rats than in SO rats. Lactate infusion failed to increase the rate of glucose production in perfused livers of both HX and SO rats and there was no significant difference in the activity of hepatic phosphoenolpyruvate carboxykinase. By contrast, fructose infusion elicited a large increase in glucose production in the perfused livers of HX rats at 24 and 48 h after PH. The increase was closely associated with not the change in fructose 2,6-bisphosphate levels but the increment of the intracellular levels of citrate. Treatment of octanoate or oleate, which supplies acetyl-CoA via fatty acid oxidation, mimicked the fructose-induced increase in glucose production in SO rats with a concomitant increase in hepatic levels of citrate. These results suggest that the oxidation of FFA may play an important role in glucose production induced by fructose administration during the early phase of liver regeneration.</description><subject>Acetyl Coenzyme A - metabolism</subject><subject>acetyl-CoA</subject><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>citrate</subject><subject>Citrates - metabolism</subject><subject>Energy Intake</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>free fatty acids</subject><subject>fructose</subject><subject>Fructose - metabolism</subject><subject>fructose 2,6-bisphosphate</subject><subject>Fructosephosphates - metabolism</subject><subject>Gluconeogenesis</subject><subject>glucose</subject><subject>Glucose - metabolism</subject><subject>Hepatectomy</subject><subject>Kinetics</subject><subject>Lactates - metabolism</subject><subject>Liver - metabolism</subject><subject>liver regeneration</subject><subject>Liver Regeneration - physiology</subject><subject>Male</subject><subject>Phosphoenolpyruvate Carboxykinase (GTP) - metabolism</subject><subject>Pyruvates - metabolism</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reference Values</subject><issn>0003-9861</issn><issn>1096-0384</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kEFv1DAQRi0EapfSK0fwiVuWmTjJxke06raVVqKi7dnY8XhrlI0XOynqv8dReuDCaUaaN9-MHmMfEdYI0HzVxvg1SinXWJXlG7ZCkE0Boq3eshUAiEK2DZ6z9yn9AkCsmvKMnSPUZV22csV-bp_0cKDE_cB3cerGkKi4HezUkeV3MeRm9GHgwfHrfurydCbHJ-I_9Mj3_pki34W-D3_8cOB3Oo5e9_yGTnqkHHZ8-cDeOd0nunytF-xxd_WwvSn2369vt9_2RSdQjoV1WNsWBBqjxcZasKArrBtbbZoNOde1Bk1TapIIpbTonAFrSFoyWANIccG-LLmnGH5PlEZ19KmjvtcDhSmpDbRVLUSZwfUCdjGkFMmpU_RHHV8Ugpqdqtmpmp2q2Wle-PSaPJkj2X_wRWIGPi-A00HpQ_RJPd6XgCJ_irJtm0y0C0HZwLOnqFLnaciOfcyalA3-f9f_AjAwj7k</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>Moriyama, Mitsuaki</creator><creator>Nishisako, Mototaka</creator><creator>Ueda, Junko</creator><creator>Kannan, Yukiko</creator><creator>Ohta, Mitsuaki</creator><creator>Sugano, Tsukasa</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991101</creationdate><title>Changes in Fructose-Induced Production of Glucose in the Rat Liver Following Partial Hepatectomy</title><author>Moriyama, Mitsuaki ; Nishisako, Mototaka ; Ueda, Junko ; Kannan, Yukiko ; Ohta, Mitsuaki ; Sugano, Tsukasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-df15d8031bba37dd0d0a4156d4767effc8b1b62ae91029d1ffb0dbe9deb150093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetyl Coenzyme A - metabolism</topic><topic>acetyl-CoA</topic><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>citrate</topic><topic>Citrates - metabolism</topic><topic>Energy Intake</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>free fatty acids</topic><topic>fructose</topic><topic>Fructose - metabolism</topic><topic>fructose 2,6-bisphosphate</topic><topic>Fructosephosphates - metabolism</topic><topic>Gluconeogenesis</topic><topic>glucose</topic><topic>Glucose - metabolism</topic><topic>Hepatectomy</topic><topic>Kinetics</topic><topic>Lactates - metabolism</topic><topic>Liver - metabolism</topic><topic>liver regeneration</topic><topic>Liver Regeneration - physiology</topic><topic>Male</topic><topic>Phosphoenolpyruvate Carboxykinase (GTP) - metabolism</topic><topic>Pyruvates - metabolism</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moriyama, Mitsuaki</creatorcontrib><creatorcontrib>Nishisako, Mototaka</creatorcontrib><creatorcontrib>Ueda, Junko</creatorcontrib><creatorcontrib>Kannan, Yukiko</creatorcontrib><creatorcontrib>Ohta, Mitsuaki</creatorcontrib><creatorcontrib>Sugano, Tsukasa</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moriyama, Mitsuaki</au><au>Nishisako, Mototaka</au><au>Ueda, Junko</au><au>Kannan, Yukiko</au><au>Ohta, Mitsuaki</au><au>Sugano, Tsukasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Fructose-Induced Production of Glucose in the Rat Liver Following Partial Hepatectomy</atitle><jtitle>Archives of biochemistry and biophysics</jtitle><addtitle>Arch Biochem Biophys</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>371</volume><issue>1</issue><spage>53</spage><epage>62</epage><pages>53-62</pages><issn>0003-9861</issn><eissn>1096-0384</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The fructose-induced production of glucose in the liver after partial hepatectomy (PH) was evaluated by using the liver-perfusion system. There was no significant difference in plasma glucose level between hepatectomized (HX) and sham-operated (SO) rats at 24 h after surgery, and, thereafter, almost similar levels were obtained in both groups. However, the level of serum free fatty acids (FFA) was significantly higher in HX rats than that in SO rats at 24 and 48 h after surgery. When both groups of rats were given fructose by gavage, the increment of plasma glucose was significantly larger in HX rats than in SO rats. Lactate infusion failed to increase the rate of glucose production in perfused livers of both HX and SO rats and there was no significant difference in the activity of hepatic phosphoenolpyruvate carboxykinase. By contrast, fructose infusion elicited a large increase in glucose production in the perfused livers of HX rats at 24 and 48 h after PH. The increase was closely associated with not the change in fructose 2,6-bisphosphate levels but the increment of the intracellular levels of citrate. Treatment of octanoate or oleate, which supplies acetyl-CoA via fatty acid oxidation, mimicked the fructose-induced increase in glucose production in SO rats with a concomitant increase in hepatic levels of citrate. These results suggest that the oxidation of FFA may play an important role in glucose production induced by fructose administration during the early phase of liver regeneration.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10525289</pmid><doi>10.1006/abbi.1999.1422</doi><tpages>10</tpages></addata></record> |
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| subjects | Acetyl Coenzyme A - metabolism acetyl-CoA Animals Blood Glucose - metabolism citrate Citrates - metabolism Energy Intake Fatty Acids, Nonesterified - blood free fatty acids fructose Fructose - metabolism fructose 2,6-bisphosphate Fructosephosphates - metabolism Gluconeogenesis glucose Glucose - metabolism Hepatectomy Kinetics Lactates - metabolism Liver - metabolism liver regeneration Liver Regeneration - physiology Male Phosphoenolpyruvate Carboxykinase (GTP) - metabolism Pyruvates - metabolism Rats Rats, Sprague-Dawley Reference Values |
| title | Changes in Fructose-Induced Production of Glucose in the Rat Liver Following Partial Hepatectomy |
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