Effects of bromantan on offspring maturation and development of reflexes

Bromantan ( N-[2-adamantil]- N-[ para-bromphenyl]amine) is an “actoprotective” drug widely used in Russia as a muscle performance-enhancing agent for sportsmen and as an immunostimulator in medicine. Experiments were conducted to determine whether this compound has adverse effects on the reproductio...

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Bibliographic Details
Published in:Neurotoxicology and teratology 2001-03, Vol.23 (2), p.213-222
Main Authors: Iezhitsa, Igor N., Spasov, Alexander A., Bugaeva, Lubov I.
Format: Article
Language:English
Subjects:
Adamantane
Amantadine - analogs & derivatives
Amantadine - pharmacology
Animals
Avoidance Learning - drug effects
Body Weight - drug effects
bromantan
Dose-Response Relationship, Drug
Female
Growth - drug effects
Hand Strength
Motor Activity - drug effects
Offsprings development and maturation
Open-field test
Passive avoidance test
Physical development
Postural Balance - drug effects
Pregnancy
Psychotropic Drugs - pharmacology
Rats
Rats, Wistar
Reflex - drug effects
Sensorimotor reflexes
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Summary:Bromantan ( N-[2-adamantil]- N-[ para-bromphenyl]amine) is an “actoprotective” drug widely used in Russia as a muscle performance-enhancing agent for sportsmen and as an immunostimulator in medicine. Experiments were conducted to determine whether this compound has adverse effects on the reproduction and development of offspring. Sexually mature female rats, weighing 180–200 g, were orally given bromantan at doses of 30 mg/kg (30-mg/kg group), 150 mg/kg (150-mg/kg group) and 600 mg/kg (600-mg/kg group) daily for 16 days, while the controls received the vehicle, amylaceous solution. Afterwards, treated females were mated with untreated males. The body weight change of the pregnant rats was monitored, as well as the length of gestation, litter size, sex ratio and number of stillborn. The offsprings were weighed and observed for external malformations, abnormalities of conditioned and unconditioned reflexes and open-field behaviour. Observation of rat dams revealed that their general state and activity in all groups did not differ significantly both during and after bromantan treatment. Bromantan had no adverse effects on body weight and gestation length of dams. Number of dams delivered per group did not differ from controls. There were stillborn rat pups in all litters, but the control group had less. One dam in the first group delivered a rat pup with a head hematoma. Litter size of the 30- and 600-mg/kg groups was decreased (by 34.9% and 44.2%, respectively) and increased in the 150-mg/kg group (by 45.1%, P
ISSN:0892-0362
1872-9738
DOI:10.1016/S0892-0362(01)00119-2