Long-term Re-treatment with Interferon and Ribavirin Combination Therapy in Patients with Chronic Hepatitis C who are Non-responders to Interferon Alone: a Preliminary Study

We evaluated the efficacy and tolerance of ribavirin and IFN-alpha combination therapy over 12 months in 28 patients who were non-responders to IFN-alpha alone. Of 24 patients who have finished the therapy, 6 (25%) obtained a complete response (normal ALT and negative HCV RNA) at the end of treatmen...

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Bibliographic Details
Published in:Scandinavian journal of infectious diseases 1999, Vol.31 (4), p.359-361
Main Authors: VEGA, P, CASTRO, A, HERMIDA, M, LOPEZ CALVO, S, PEDREIRA, J
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - administration & dosage
Biological and medical sciences
Drug Therapy, Combination
Female
Hepacivirus - isolation & purification
Hepatitis C virus
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - virology
Humans
Interferons - administration & dosage
Long-Term Care
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prognosis
Prospective Studies
Retreatment
Ribavirin - administration & dosage
Spain
Statistics, Nonparametric
Treatment Failure
Treatment Outcome
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Summary:We evaluated the efficacy and tolerance of ribavirin and IFN-alpha combination therapy over 12 months in 28 patients who were non-responders to IFN-alpha alone. Of 24 patients who have finished the therapy, 6 (25%) obtained a complete response (normal ALT and negative HCV RNA) at the end of treatment and maintained a sustained response 27% (5/18).
ISSN:0036-5548
1651-1980
DOI:10.1080/00365549950163789