Familial Resemblance in Humoral Immune Response to Defined and Crude Schistosoma mansoni Antigens in an Endemic Area in Brazil

This study addressed whether the humoral immune response to crude and defined Schistosoma mansoni antigens aggregates within families. The sample included 155 siblings from 42 nuclear families in Brazil. Sera examined by ELISA for antibody isotypes reactive to defined schistosome antigens and crude...

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Bibliographic Details
Published in:The Journal of infectious diseases 1999-11, Vol.180 (5), p.1665-1673
Main Authors: Bethony, J., Silveira, A. M. S., Alves-Oliveira, L. F., Thakur, A., Gazzinelli, G., Correa-Oliveira, R., LoVerde, P. T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antibodies
Antibodies, Helminth - blood
Antigens
Antigens, Helminth - immunology
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Correlation coefficients
Correlations
Diseases caused by trematodes
Endemic Diseases
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Helminthic diseases
Humans
Immunity, Innate - genetics
Immunoglobulin Isotypes - blood
Infant
Infections
Infectious diseases
Isotypes
Life cycle. Host-agent relationship. Pathogenesis
Major Articles
Male
Medical sciences
Nuclear Family
Parasite Egg Count
Parasitic diseases
Parents
Protozoa
Schistosoma mansoni - growth & development
Schistosoma mansoni - immunology
Schistosomiases
Schistosomiasis
Schistosomiasis mansoni - epidemiology
Schistosomiasis mansoni - genetics
Schistosomiasis mansoni - immunology
Siblings
T lymphocytes
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Summary:This study addressed whether the humoral immune response to crude and defined Schistosoma mansoni antigens aggregates within families. The sample included 155 siblings from 42 nuclear families in Brazil. Sera examined by ELISA for antibody isotypes reactive to defined schistosome antigens and crude schistosome antigens (soluble adult worm antigen preparation and soluble egg antigen) demonstrated that there was a difference in sibling-pair correlations between defined and crude S. mansoni antigens. In contrast to the finding with crude antigens, egg-positive sibling pairs showed significant familial resemblance for all IgG subclasses and IgE to adult-stage antigens Smp20.8 and Smp50. Only the IgE and IgG4 isotypes showed familial resemblance to the egg-stage antigen, Smp40. Egg-negative sibling pairs showed significant familial resemblance only for IgE and IgG4 to Smp40. That both the IgE and IgG4 response to defined S. mansoni antigens showed familial resemblance is interesting in light of the converging evidence for the role of IgE and IgG4 in human susceptibility and resistance to reinfection.
ISSN:0022-1899
1537-6613
DOI:10.1086/315069