A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark

Along with three known drimanes, polygodial, 1-β-( p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive act...

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Bibliographic Details
Published in:Phytochemistry (Oxford) 2001-05, Vol.57 (1), p.103-107
Main Authors: Malheiros, Angela, Filho, Valdir Cechinel, Schmitt, Clarisse B, Santos, Adair R.S, Scheidt, Cristiano, Calixto, João B, Monache, Franco Delle, Yunes, Rosendo A
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Antinociception
Biological and medical sciences
Chemical constitution
Drimanial
Drimys winteri
Fundamental and applied biological sciences. Psychology
General pharmacology
Magnetic Resonance Spectroscopy
Magnoliopsida - chemistry
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant physiology and development
Sesquiterpene drimane
Sesquiterpenes - chemistry
Sesquiterpenes - pharmacology
Spectrum Analysis
Winteraceae
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Summary:Along with three known drimanes, polygodial, 1-β-( p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
ISSN:0031-9422
1873-3700
DOI:10.1016/S0031-9422(00)00515-X