A novel translocation t(2;9)(q14;p12) in AML-M2 with an uncommon phenotype: myeloperoxidase-positive and myeloid antigen-negative

We report a case of acute myeloid leukemia (AML-M2) expressing myeloperoxidase (MPO) but no myeloid antigens. A few cases with this discordant phenotype have been reported and an association has been suggested between the lack of CD13 and CD33 in MPO positive AML and the presence of t(8;21). Cytogen...

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Bibliographic Details
Published in:Leukemia research 2001-06, Vol.25 (6), p.501-507
Main Authors: Specchia, Giorgina, Mestice, Anna, Clelia Storlazzi, Tiziana, Anelli, Luisa, Pannunzio, Alessandra, Grazia Roberti, Maria, Rocchi, Mariano, Liso, Vincenzo
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adult
Aged
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Biological and medical sciences
CD13 antigen
CD13 Antigens - analysis
CD33 antigen
Child
chromosome 2
chromosome 9
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 9
Discordant phenotype
Hematologic and hematopoietic diseases
Humans
Leukemia, Myeloid, Acute - enzymology
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Middle Aged
Myeloid antigen
Myeloperoxidase
Peroxidase - metabolism
Sialic Acid Binding Ig-like Lectin 3
t(2
9)
t(8
21)
Translocation, Genetic
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Summary:We report a case of acute myeloid leukemia (AML-M2) expressing myeloperoxidase (MPO) but no myeloid antigens. A few cases with this discordant phenotype have been reported and an association has been suggested between the lack of CD13 and CD33 in MPO positive AML and the presence of t(8;21). Cytogenetic and molecular analyses performed in our case showed 48,XY,+Y,+8,t(2;9)(q14;p12). We believe that combined approaches can contribute to detect particular AL cases like the present one, that confirms the heterogeneity of AML. However, further studies are needed to clarify the relationship between phenotypic aberrations and cytogenetic abnormalities.
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(00)00160-0