Anti-human skeletal muscle glycolipid antibodies in unstable angina

Background We studied whether the level of anti–skeletal muscle glycolipid antibodies (AGA), a marker of acute rejection in heart transplantation, may be associated with an adverse prognosis in unstable angina. Methods and Results The in-hospital evolution of 50 patients with unstable angina (Braunw...

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Bibliographic Details
Published in:The American heart journal 2001-05, Vol.141 (5), p.780-783
Main Authors: Laguens, Rubén P., Vigliano, Carlos A., Macchia, Alejandro, Argel, María I., Chambó, Jorge G., Gurfinkel, Enrique P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Angina, Unstable - blood
Angina, Unstable - immunology
Autoantibodies - blood
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary heart disease
Disease Progression
Enzyme-Linked Immunosorbent Assay
Female
Glycolipids - immunology
Heart
Humans
Male
Medical sciences
Middle Aged
Muscle, Skeletal - immunology
Prognosis
Tropical medicine
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Summary:Background We studied whether the level of anti–skeletal muscle glycolipid antibodies (AGA), a marker of acute rejection in heart transplantation, may be associated with an adverse prognosis in unstable angina. Methods and Results The in-hospital evolution of 50 patients with unstable angina (Braunwald class III B) was assessed. We determined the incidence of death, myocardial infarction, and refractory angina. Blood was collected at admission and 24 hours later for determination of AGA levels by enzyme-linked immunosorbent assay. Twenty-three patients showed a decrease in the AGA level at 24 hours after admission. Ten in-hospital cardiac events occurred in these patients (43.4%) as compared with 4 (14.8%) in the 27 patients who did not show a decrease (P =.025). In patients with previous myocardial infarction (n = 26), the AGA assay was a powerful predictor of outcome. In this subgroup, 66.6% of patients who had decreased AGA levels (8 of 12) had cardiac events as compared with 14.2% (2 of 14) of those who did not have that decrease (P =.001). Conclusions We conclude that a decrease of AGA levels 24 hours after admission is associated with a complicated in-hospital course. This finding may provide new insights in the phenomenon of plaque instability involved in the development of acute coronary syndromes. (Am Heart J 2001;141:780-3.)
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2001.114801