Paying attention to the cerebrovascular system in glaucoma

Abstract In glaucoma, damage to vision pathways in the brain may contribute to vision dysfunction and loss. A large part of the central visual system is located within a watershed area of increased susceptibility to ischemic injury. In addition to glaucomatous central visual neuron injury, glaucoma...

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Bibliographic Details
Published in:Canadian journal of ophthalmology 2008-06, Vol.43 (3), p.342-346
Main Authors: Yücel, Yeni H., MD, PhD, FRCPC, Gupta, Neeru, MD, PhD, FRCSC
Format: Article
Language:English
Subjects:
Brain - blood supply
cerebral blood flow
Cerebrovascular Circulation - physiology
Cerebrovascular Disorders - physiopathology
comorbid
Glaucoma - physiopathology
Humans
Internal Medicine
ischemia
ocular blood flow
Ophthalmology
small vessel disease
stroke
vascular disease
Visual Pathways - physiopathology
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Summary:Abstract In glaucoma, damage to vision pathways in the brain may contribute to vision dysfunction and loss. A large part of the central visual system is located within a watershed area of increased susceptibility to ischemic injury. In addition to glaucomatous central visual neuron injury, glaucoma patients may suffer silent vascular insults from cerebral small blood vessel disease.We hypothesize that “double-hit” mechanisms of injury, such as glaucoma and comorbid cerebrovascular conditions, play a role in glaucomatous susceptibility and disease manifestations in young and aging populations at risk.
ISSN:0008-4182
1715-3360
DOI:10.3129/i08-059