Interferon-β Signaling Is Enhanced in Patients With Insufficient Coronary Collateral Artery Development and Inhibits Arteriogenesis in Mice

Stimulation of collateral artery growth in patients has been hitherto unsuccessful, despite promising experimental approaches. Circulating monocytes are involved in the growth of collateral arteries, a process also referred to as arteriogenesis. Patients show a large heterogeneity in their natural a...

Full description

Saved in:
Bibliographic Details
Published in:Circulation research 2008-05, Vol.102 (10), p.1286-1294
Main Authors: Schirmer, Stephan H, Fledderus, Joost O, Bot, Pieter T.G, Moerland, Perry D, Hoefer, Imo E, Baan, Jan, Henriques, José P.S, van der Schaaf, René J, Vis, Marije M, Horrevoets, Anton J.G, Piek, Jan J, van Royen, Niels
Format: Article
Language:English
Subjects:
Aged
Animals
Apoptosis - genetics
Biological and medical sciences
Cells, Cultured
Collateral Circulation - drug effects
Collateral Circulation - physiology
Coronary Artery Disease - genetics
Coronary Artery Disease - metabolism
Coronary Artery Disease - physiopathology
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Fundamental and applied biological sciences. Psychology
Genetic Variation
Hindlimb - blood supply
Humans
Interferon-beta - genetics
Interferon-beta - metabolism
Interferon-beta - pharmacology
Ischemia - genetics
Ischemia - metabolism
Ischemia - physiopathology
Lipopolysaccharides - pharmacology
Macrophages - cytology
Macrophages - drug effects
Macrophages - physiology
Mice
Middle Aged
Monocytes - cytology
Monocytes - drug effects
Monocytes - physiology
Muscle, Smooth, Vascular - cytology
Muscle, Smooth, Vascular - physiology
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction - drug effects
Signal Transduction - physiology
Stem Cells - cytology
Stem Cells - physiology
Vertebrates: cardiovascular system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stimulation of collateral artery growth in patients has been hitherto unsuccessful, despite promising experimental approaches. Circulating monocytes are involved in the growth of collateral arteries, a process also referred to as arteriogenesis. Patients show a large heterogeneity in their natural arteriogenic response on arterial obstruction. We hypothesized that circulating cell transcriptomes would provide mechanistic insights and new therapeutic strategies to stimulate arteriogenesis. Collateral flow index was measured in 45 patients with single-vessel coronary artery disease, separating collateral responders (collateral flow index, >0.21) and nonresponders (collateral flow index, ≤0.21). Isolated monocytes were stimulated with lipopolysaccharide or taken into macrophage culture for 20 hours to mimic their phenotype during arteriogenesis. Genome-wide mRNA expression analysis revealed 244 differentially expressed genes (adjusted P,
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.108.171827