Asymmetric catalysis with bifunctional cinchona alkaloid-based urea and thiourea organocatalysts

Cinchona alkaloid derivatives modified to include a (thio)urea component have emerged in the last three years as readily accessible, robust and tunable bifunctional organocatalysts for a range of synthetically useful transformations. The origins of these catalysts and the major developments in their...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2008-06 (22), p.2499-2510
Main Author: Connon, Stephen J
Format: Article
Language:English
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Summary:Cinchona alkaloid derivatives modified to include a (thio)urea component have emerged in the last three years as readily accessible, robust and tunable bifunctional organocatalysts for a range of synthetically useful transformations. The origins of these catalysts and the major developments in their application in enantioselective synthesis are reviewed.
ISSN:1359-7345
1364-548X
DOI:10.1039/b719249e