A dipeptide YY derived from royal jelly proteins inhibits renin activity

Renin is the rate limiting enzyme in the renin-angiotensin (RA) system that regulates blood pressure and electrolyte balance. In this study, we investigated the renin inhibitory effect of a royal jelly (RJ)-derived peptide. A dipeptide YY was isolated from the digested fraction of RJ proteins by pro...

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Bibliographic Details
Published in:International journal of molecular medicine 2008-06, Vol.21 (6), p.677-681
Main Authors: Sultana, Afroza, Nurun Nabi, A, Nasir, Uddin, Maruyama, Hiroe, Suzuki, Kazu-Michi, Mishima, Satoshi, Suzuki, Fumiaki
Format: Article
Language:English
Subjects:
Angiotensinogen - genetics
Angiotensinogen - metabolism
Animals
Blood Pressure - drug effects
CHO Cells
Chromatography, High Pressure Liquid
Cricetinae
Cricetulus
Dipeptides - chemistry
Dipeptides - metabolism
Dipeptides - pharmacology
DNA, Complementary - genetics
Enzyme-Linked Immunosorbent Assay
Fatty Acids - chemistry
Fatty Acids - isolation & purification
Fatty Acids - metabolism
Female
Gene Transfer Techniques
Genetic Vectors - genetics
Humans
Hypertension - physiopathology
Hypertension - prevention & control
Insect Proteins - chemistry
Insect Proteins - isolation & purification
Insect Proteins - metabolism
Molecular Structure
Peptide Hydrolases - metabolism
Rats
Rats, Inbred SHR
Recombinant Proteins - metabolism
Renin - genetics
Renin - metabolism
Renin-Angiotensin System - drug effects
Sheep
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Summary:Renin is the rate limiting enzyme in the renin-angiotensin (RA) system that regulates blood pressure and electrolyte balance. In this study, we investigated the renin inhibitory effect of a royal jelly (RJ)-derived peptide. A dipeptide YY was isolated from the digested fraction of RJ proteins by proteases and was found to inhibit human renin activity. The inhibition constant (Ki) of YY was estimated to be 10 μM when the Km was 0.16 μM using sheep angiotensinogen as the substrate. The peptide was observed to lower blood pressure in spontaneously hypertensive rats.
ISSN:1107-3756