Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss

Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anth...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 2008-06, Vol.19 (6), p.371-375
Main Authors: Jung, Sun Hye, Park, Hye Soon, Kim, Kyung-Soo, Choi, Woong H., Ahn, Chul Woo, Kim, Bom Taeck, Kim, Seon Mee, Lee, Seon Yeong, Ahn, Sang Mi, Kim, Yun Kyung, Kim, Hae Jin, Kim, Dae Jung, Lee, Kwan-Woo
Format: Article
Language:English
Subjects:
Adipocytokines (adipokines)
adipokines
adiponectin
Adolescent
Adult
adults
Aged
anthropometric measurements
blood lipids
blood serum
body fat
body mass index
Caloric Restriction
cholesterol
cytokines
Cytokines - blood
diet-related diseases
dieting
disease prevention
drug therapy
exercise
Female
Humans
hypertension
immune system
insulin resistance
Interleukin (IL) 10
interleukin-10
Interleukin-10 - blood
interleukin-6
leptin
Male
Middle Aged
noninsulin-dependent diabetes mellitus
obesity
Obesity - blood
Obesity - diet therapy
obesity-related diseases
resistin
triacylglycerols
tumor necrosis factors
very low calorie diet
waist circumference
waist-to-hip ratio
weight control programs
Weight loss
Weight Loss - physiology
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Summary:Obesity is a major risk factor for hypertension, coronary artery disease and type 2 diabetes. Weight loss is associated with significant metabolic benefits. Our objective was to examine changes in adipocytokines and interleukin (IL) 10 in obese subjects before and after weight loss. We measured anthropometric parameters, adipocytokine and IL-10 in 78 obese people who had visited obesity clinics at five university hospitals (Ajou, Ulsan, Catholic, Hanyang and Yonsei) in Korea. They restricted their caloric intake to less than their usual intake (by 500kcal), were administered sibutramine and were given a program of exercise for 12 weeks. After 12 weeks, weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio, total body fat, total cholesterol, triglyceride, tumor necrosis factor α (TNF-α), IL-6, resistin and leptin had significantly decreased, while adiponectin and IL-10 had significantly increased. A bivariate correlation analysis found that increment in IL-10 and baseline IL-10 levels significantly correlated with decrement in TNF-α ( P
ISSN:0955-2863
1873-4847
DOI:10.1016/j.jnutbio.2007.05.007