Synthesis and water-swelling of thermo-responsive poly(ester urethane)s containing poly(ε-caprolactone), poly(ethylene glycol) and poly(propylene glycol)

Abstract Thermo-responsive multiblock poly(ester urethane)s comprising poly(ε-caprolactone) (PCL), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG) segments were synthesized. The copolymers were characterized by GPC, NMR, FTIR, XRD, DSC and TGA. Water-swelling analysis carried out at di...

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Bibliographic Details
Published in:Biomaterials 2008-08, Vol.29 (22), p.3185-3194
Main Authors: Loh, Xian Jun, Colin Sng, Kian Boon, Li, Jun
Format: Article
Language:English
Subjects:
Advanced Basic Science
Biodegradable
Dentistry
Magnetic Resonance Spectroscopy
Molecular Structure
Poly(ester urethane)
Poly(ethylene glycol)
Poly(propylene glycol)
Poly(ε-caprolactone)
Polyesters - chemical synthesis
Polyesters - chemistry
Polyethylene Glycols - chemical synthesis
Polyethylene Glycols - chemistry
Polyurethanes - chemistry
Propylene Glycols - chemical synthesis
Propylene Glycols - chemistry
Stimuli-responsive
Temperature
Water - chemistry
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Summary:Abstract Thermo-responsive multiblock poly(ester urethane)s comprising poly(ε-caprolactone) (PCL), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG) segments were synthesized. The copolymers were characterized by GPC, NMR, FTIR, XRD, DSC and TGA. Water-swelling analysis carried out at different temperatures revealed that the bulk hydrophilicity of the copolymers could be controlled either by adjusting the composition of the copolymer or by changing the temperature of the environment. These thermo-responsive copolymer films formed highly swollen hydrogel-like materials when soaked in cold water and shrank when soaked in warm water. The changes are reversible. The mechanical properties of the copolymer films were assessed by tensile strength measurement. These copolymers were ductile when compared to PCL homopolymers. Young's modulus and the stress at break increased with increasing PCL content, whereas the strain at break increased with increasing PEG content. The results of the cytotoxicity tests based on the ISO 10993-5 protocol demonstrated that the copolymers were non-cytotoxic and could be potentially used in biomedical applications.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2008.04.015