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Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer
Background: The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer. Methods: One hundred and eighty patients with colorectal cance...
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| Published in: | British journal of surgery 2007-08, Vol.94 (8), p.1028-1032 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 1032 |
| container_issue | 8 |
| container_start_page | 1028 |
| container_title | British journal of surgery |
| container_volume | 94 |
| creator | Crozier, J. E. M. McKee, R. F. McArdle, C. S. Angerson, W. J. Anderson, J. H. Horgan, P. G. McMillan, D. C. |
| description | Background:
The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
Methods:
One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C‐reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
Results:
The peak in CRP concentration occurred on day 2 (P < 0·001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0·002), a raised preoperative CRP level (P < 0·001) and the presence of hypoalbuminaemia (P = 0·043) were associated with poorer cancer‐specific survival.
Conclusion:
Preoperative but not postoperative CRP concentrations are associated with poor tumour‐specific survival in patients undergoing potentially curative resection for colorectal cancer. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Reflects systemic manifestations |
| doi_str_mv | 10.1002/bjs.5706 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_70746251</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70746251</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3886-9c8337c99e5e657265ea28b97e5e0620cd79c25b349867f8e26036dde0083eba3</originalsourceid><addsrcrecordid>eNpF0U1vEzEQBmCrArVpi8QvQHuB25ZZO_7YI60gbYkAiSKOlteZCBfverG9afPv66ihOY3G82gkz0vI2wYuGgD6sbtPF1yCOCKzhgle00aoV2QGALJuGGUn5DSle4CGAafH5KSRcyYphxkJPyKGEaPJboNVN-VqCLkaQ8qH17RNGXtnKzesvel7k0PcVhHTGIaElQ0xojcZU_Xg8p8qTXHjNsYXXmY-RLS5dNYMFuM5eb02PuGbfT0jv758vru6rpffFzdXn5a1ZUqJurWKMWnbFjkKLqngaKjqWll6EBTsSraW8o7NWyXkWiEVwMRqhQCKYWfYGfnwvHeM4d-EKeveJYvemwHDlLQEOReUNwW-28Op63Glx-h6E7f6_4kKeL8HJlnj17H8w6WDU-0cKN25-tk9OI_bwxz0LiJdItK7iPTl7c9dPXhXrvv44k38q4Vkkuvf3xZafm2Xl6Du9II9Aa04k-A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70746251</pqid></control><display><type>article</type><title>Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer</title><source>Wiley-Blackwell Journals</source><source>Oxford University Press Journals</source><creator>Crozier, J. E. M. ; McKee, R. F. ; McArdle, C. S. ; Angerson, W. J. ; Anderson, J. H. ; Horgan, P. G. ; McMillan, D. C.</creator><creatorcontrib>Crozier, J. E. M. ; McKee, R. F. ; McArdle, C. S. ; Angerson, W. J. ; Anderson, J. H. ; Horgan, P. G. ; McMillan, D. C.</creatorcontrib><description>Background:
The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
Methods:
One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C‐reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
Results:
The peak in CRP concentration occurred on day 2 (P < 0·001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0·002), a raised preoperative CRP level (P < 0·001) and the presence of hypoalbuminaemia (P = 0·043) were associated with poorer cancer‐specific survival.
Conclusion:
Preoperative but not postoperative CRP concentrations are associated with poor tumour‐specific survival in patients undergoing potentially curative resection for colorectal cancer. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Reflects systemic manifestations</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.5706</identifier><identifier>PMID: 17437250</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; C-Reactive Protein - metabolism ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - surgery ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Humans ; Intraoperative Complications - mortality ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Systemic Inflammatory Response Syndrome - mortality ; Tumors</subject><ispartof>British journal of surgery, 2007-08, Vol.94 (8), p.1028-1032</ispartof><rights>Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.</rights><rights>2007 INIST-CNRS</rights><rights>Copyright (c) 2007 British Journal of Surgery Society Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3886-9c8337c99e5e657265ea28b97e5e0620cd79c25b349867f8e26036dde0083eba3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.5706$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.5706$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18940220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17437250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crozier, J. E. M.</creatorcontrib><creatorcontrib>McKee, R. F.</creatorcontrib><creatorcontrib>McArdle, C. S.</creatorcontrib><creatorcontrib>Angerson, W. J.</creatorcontrib><creatorcontrib>Anderson, J. H.</creatorcontrib><creatorcontrib>Horgan, P. G.</creatorcontrib><creatorcontrib>McMillan, D. C.</creatorcontrib><title>Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Background:
The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
Methods:
One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C‐reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
Results:
The peak in CRP concentration occurred on day 2 (P < 0·001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0·002), a raised preoperative CRP level (P < 0·001) and the presence of hypoalbuminaemia (P = 0·043) were associated with poorer cancer‐specific survival.
Conclusion:
Preoperative but not postoperative CRP concentrations are associated with poor tumour‐specific survival in patients undergoing potentially curative resection for colorectal cancer. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Reflects systemic manifestations</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>C-Reactive Protein - metabolism</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Humans</subject><subject>Intraoperative Complications - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prospective Studies</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Systemic Inflammatory Response Syndrome - mortality</subject><subject>Tumors</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNpF0U1vEzEQBmCrArVpi8QvQHuB25ZZO_7YI60gbYkAiSKOlteZCBfverG9afPv66ihOY3G82gkz0vI2wYuGgD6sbtPF1yCOCKzhgle00aoV2QGALJuGGUn5DSle4CGAafH5KSRcyYphxkJPyKGEaPJboNVN-VqCLkaQ8qH17RNGXtnKzesvel7k0PcVhHTGIaElQ0xojcZU_Xg8p8qTXHjNsYXXmY-RLS5dNYMFuM5eb02PuGbfT0jv758vru6rpffFzdXn5a1ZUqJurWKMWnbFjkKLqngaKjqWll6EBTsSraW8o7NWyXkWiEVwMRqhQCKYWfYGfnwvHeM4d-EKeveJYvemwHDlLQEOReUNwW-28Op63Glx-h6E7f6_4kKeL8HJlnj17H8w6WDU-0cKN25-tk9OI_bwxz0LiJdItK7iPTl7c9dPXhXrvv44k38q4Vkkuvf3xZafm2Xl6Du9II9Aa04k-A</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Crozier, J. E. M.</creator><creator>McKee, R. F.</creator><creator>McArdle, C. S.</creator><creator>Angerson, W. J.</creator><creator>Anderson, J. H.</creator><creator>Horgan, P. G.</creator><creator>McMillan, D. C.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer</title><author>Crozier, J. E. M. ; McKee, R. F. ; McArdle, C. S. ; Angerson, W. J. ; Anderson, J. H. ; Horgan, P. G. ; McMillan, D. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3886-9c8337c99e5e657265ea28b97e5e0620cd79c25b349867f8e26036dde0083eba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>C-Reactive Protein - metabolism</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Humans</topic><topic>Intraoperative Complications - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prospective Studies</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Systemic Inflammatory Response Syndrome - mortality</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crozier, J. E. M.</creatorcontrib><creatorcontrib>McKee, R. F.</creatorcontrib><creatorcontrib>McArdle, C. S.</creatorcontrib><creatorcontrib>Angerson, W. J.</creatorcontrib><creatorcontrib>Anderson, J. H.</creatorcontrib><creatorcontrib>Horgan, P. G.</creatorcontrib><creatorcontrib>McMillan, D. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crozier, J. E. M.</au><au>McKee, R. F.</au><au>McArdle, C. S.</au><au>Angerson, W. J.</au><au>Anderson, J. H.</au><au>Horgan, P. G.</au><au>McMillan, D. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>2007-08</date><risdate>2007</risdate><volume>94</volume><issue>8</issue><spage>1028</spage><epage>1032</epage><pages>1028-1032</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><notes>istex:48359580F58E81085B43F85AA532A2700094E14B</notes><notes>ark:/67375/WNG-7K9LB08T-G</notes><notes>ArticleID:BJS5706</notes><notes>The Editors have satisfied themselves that all authors have contributed significantly to this publication</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background:
The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
Methods:
One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C‐reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
Results:
The peak in CRP concentration occurred on day 2 (P < 0·001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0·002), a raised preoperative CRP level (P < 0·001) and the presence of hypoalbuminaemia (P = 0·043) were associated with poorer cancer‐specific survival.
Conclusion:
Preoperative but not postoperative CRP concentrations are associated with poor tumour‐specific survival in patients undergoing potentially curative resection for colorectal cancer. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Reflects systemic manifestations</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>17437250</pmid><doi>10.1002/bjs.5706</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 2007-08, Vol.94 (8), p.1028-1032 |
| issn | 0007-1323 1365-2168 |
| language | eng |
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| source | Wiley-Blackwell Journals; Oxford University Press Journals |
| subjects | Adult Aged Biological and medical sciences C-Reactive Protein - metabolism Colorectal Neoplasms - blood Colorectal Neoplasms - mortality Colorectal Neoplasms - surgery Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Humans Intraoperative Complications - mortality Male Medical sciences Middle Aged Multivariate Analysis Prospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Systemic Inflammatory Response Syndrome - mortality Tumors |
| title | Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer |
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