Preoperative but not postoperative systemic inflammatory response correlates with survival in colorectal cancer

Background: The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer. Methods: One hundred and eighty patients with colorectal cance...

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Bibliographic Details
Published in:British journal of surgery 2007-08, Vol.94 (8), p.1028-1032
Main Authors: Crozier, J. E. M., McKee, R. F., McArdle, C. S., Angerson, W. J., Anderson, J. H., Horgan, P. G., McMillan, D. C.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
C-Reactive Protein - metabolism
Colorectal Neoplasms - blood
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Intraoperative Complications - mortality
Male
Medical sciences
Middle Aged
Multivariate Analysis
Prospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Systemic Inflammatory Response Syndrome - mortality
Tumors
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Summary:Background: The aim of the present study was to evaluate the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer. Methods: One hundred and eighty patients with colorectal cancer were studied. Circulating concentrations of C‐reactive protein (CRP) were measured before surgery and in the immediate postoperative period. Results: The peak in CRP concentration occurred on day 2 (P < 0·001). During the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease. Day 2 CRP concentrations were dichotomized. In univariable analysis, advanced tumour node metastasis stage (P = 0·002), a raised preoperative CRP level (P < 0·001) and the presence of hypoalbuminaemia (P = 0·043) were associated with poorer cancer‐specific survival. Conclusion: Preoperative but not postoperative CRP concentrations are associated with poor tumour‐specific survival in patients undergoing potentially curative resection for colorectal cancer. Copyright © 2007 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. Reflects systemic manifestations
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.5706