Expression of retinoid receptors in sebaceous cell carcinoma

Purpose:  The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid acid receptors (RAR‐α, RAR‐β and RAR‐γ) and retinoid X receptors (RXR‐α, RXR‐β and RXR‐γ) in sebaceous cell carcinoma. Methods:  Expression of retinoid receptors in paired spec...

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Bibliographic Details
Published in:Journal of cutaneous pathology 2006-01, Vol.33 (1), p.10-17
Main Authors: Chakravarti, Nitin, El-Naggar, Adel K., Lotan, Reuben, Anderson, James, Diwan, Abdul H., Saadati, Hossein G., Diba, Roxana, Prieto, Victor G., Esmaeli, Bita
Format: Article
Language:English
Subjects:
Adenocarcinoma, Sebaceous - metabolism
Adenocarcinoma, Sebaceous - pathology
Aged, 80 and over
Animals
Biological and medical sciences
Biomarkers, Tumor - metabolism
Cell Nucleus - metabolism
Cell Nucleus - pathology
Cytoplasm - metabolism
Cytoplasm - pathology
Dermatology
Epithelial Cells - cytology
Epithelial Cells - metabolism
Female
Humans
Immunoenzyme Techniques
Male
Medical sciences
Middle Aged
Receptors, Retinoic Acid - classification
Receptors, Retinoic Acid - metabolism
Retrospective Studies
Sebaceous Gland Neoplasms - metabolism
Sebaceous Gland Neoplasms - pathology
Signal Transduction
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Summary:Purpose:  The aim of this study is to investigate whether there are any abnormalities in the in vivo expression of retinoid acid receptors (RAR‐α, RAR‐β and RAR‐γ) and retinoid X receptors (RXR‐α, RXR‐β and RXR‐γ) in sebaceous cell carcinoma. Methods:  Expression of retinoid receptors in paired specimens of cancerous tissues (n = 10) and adjacent normal tissues (n = 10) from 10 patients with sebaceous cell carcinoma was studied immunohistochemically by using anti‐retinoid receptor antibodies. Results:  In eight of the 10 normal tissue samples, all six receptors were expressed. In the other two samples, all receptors were expressed except RAR‐γ (one sample) or RXR‐γ (two samples). Five tumours (50%) lacked RAR‐α; RAR‐α expression was lower in tumours than in normal tissues in eight of 10 cases. RAR‐β was expressed in the cytoplasm of nine of 10 tumours; RAR‐β expression was at least as high in tumours as in normal tissue in eight of 10 cases. Two tumours lacked RAR‐γ; three tumours had lower RAR‐γ expression than paired normal epithelium; four had the same RAR‐γ expression, and one had higher RAR‐γ expression. RXR‐α expression was strong in all normal tissues and tumour samples. Ten tumours lacked RXR‐β and all 10 tumours lacked RXR‐γ expression. Conclusions:  Diminished RXR‐β and RXR‐γ expression might be related to the development of sebaceous cell carcinoma. Additional studies are required to establish whether the defects in RAR expression in sebaceous cell carcinoma might affect the potential response of this tumour to treatment with retinoids.
ISSN:0303-6987
1600-0560
DOI:10.1111/j.0303-6987.2006.00396.x