Carboxyhemoglobin Elevation Due to Hemolytic Anemia

Abstract A critically ill man with drug-induced hemolytic anemia and hepatic failure was hospitalized at a private academic medical center in Seattle, Washington. Intravascular hemolysis with associated endogenous carbon monoxide (CO) production resulted in elevation of the patient’s carboxyhemoglob...

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Bibliographic Details
Published in:The Journal of emergency medicine 2007-07, Vol.33 (1), p.17-19
Main Author: Hampson, Neil B., MD
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Anemia, Hemolytic - blood
Anemia, Hemolytic - drug therapy
carbon monoxide
carboxyhemoglobin
Carboxyhemoglobin - metabolism
CO-oximetry
Emergency
Fatal Outcome
Hematocrit
hemolysis
Humans
Male
Middle Aged
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Summary:Abstract A critically ill man with drug-induced hemolytic anemia and hepatic failure was hospitalized at a private academic medical center in Seattle, Washington. Intravascular hemolysis with associated endogenous carbon monoxide (CO) production resulted in elevation of the patient’s carboxyhemoglobin (COHb) level to as high as 9.7%. Serial measurements of the patient’s COHb level were obtained and compared with other conventional measures of hemolytic activity. With the availability of new non-invasive measurement technology to detect COHb elevations, emergency clinicians are likely to see COHb elevation as a manifestation of hemolytic anemia.
ISSN:0736-4679
2352-5029
DOI:10.1016/j.jemermed.2006.10.004