Experiences with new generation vaccines against equine viral arteritis, West Nile disease and African horse sickness

Abstract Viral diseases constitute an ever growing threat to the horse industry worldwide because of the rapid movement of large numbers of horses for competition and breeding. A number of different types of vaccines are available for protective immunization of horses against viral diseases. Traditi...

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Bibliographic Details
Published in:Vaccine 2007-07, Vol.25 (30), p.5577-5582
Main Authors: MacLachlan, N. James, Balasuriya, Udeni B, Davis, Nancy L, Collier, Martha, Johnston, Robert E, Ferraro, Gregory L, Guthrie, Alan J
Format: Article
Language:English
Subjects:
African Horse Sickness - immunology
African Horse Sickness - prevention & control
African horsesickness
Allergy and Immunology
Alphavirus
Animals
Applied microbiology
Arterivirus Infections - immunology
Arterivirus Infections - prevention & control
Arterivirus Infections - veterinary
Biological and medical sciences
Commercial markets
Deoxyribonucleic acid
Disease
DNA
Equine arteritis virus
Equine viral arteritis
Fundamental and applied biological sciences. Psychology
Genomes
Herpes viruses
Horse
Horse Diseases - immunology
Horse Diseases - prevention & control
Horses
Infections
Microbiology
Proteins
Vaccines
Vaccines - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Attenuated - immunology
Vaccines, Attenuated - therapeutic use
Vaccines, DNA - immunology
Vaccines, Subunit - immunology
Vaccines, Synthetic - immunology
Viral infections
Viral Vaccines - immunology
Viral Vaccines - therapeutic use
West Nile
West Nile Fever - prevention & control
West Nile Fever - veterinary
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Summary:Abstract Viral diseases constitute an ever growing threat to the horse industry worldwide because of the rapid movement of large numbers of horses for competition and breeding. A number of different types of vaccines are available for protective immunization of horses against viral diseases. Traditional inactivated and live-attenuated (modified live virus, MLV) virus vaccines remain popular and efficacious but recombinant vaccines are increasingly being developed and used, in part because of the perceived deficiencies of some existing products. New generation vaccines include MLVs with deletions and/or mutations of critical genes, subunit vaccines that incorporate immunogenic proteins (or portions thereof) or expression vectors that produce these proteins as immunogens, and DNA vaccines. New generation vaccines have been developed for several viral diseases of horses. We recently have developed an alphavirus replicon-vectored equine arteritis virus (EAV) vaccine, and evaluated a commercial canary pox virus-vectored vaccine for West Nile disease. The success of these new-generation vaccines has catalyzed efforts to develop improved vaccines for the prevention of African horse sickness, a disease of emerging global significance.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2006.12.058