Hydroxychloroquine and Risk of Diabetes in Patients With Rheumatoid Arthritis

CONTEXT Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of diabetes mellitus. OBJECTIVE To determine the association between hydroxychloroquine use and the incidence of self-reported diabetes in a cohort of patients with rheumatoid arthr...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2007-07, Vol.298 (2), p.187-193
Main Authors: Wasko, Mary Chester M, Hubert, Helen B, Lingala, Vijaya Bharathi, Elliott, Jennifer R, Luggen, Michael E, Fries, James F, Ward, Michael M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Biological and medical sciences
Diabetes
Diabetes Mellitus - epidemiology
Diabetes. Impaired glucose tolerance
Diseases of the osteoarticular system
Drug therapy
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
General aspects
Humans
Hydroxychloroquine - therapeutic use
Inflammatory joint diseases
Kaplan-Meier Estimate
Longitudinal Studies
Male
Medical sciences
Middle Aged
Poisson Distribution
Proportional Hazards Models
Rheumatoid arthritis
Risk
Risk factors
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Summary:CONTEXT Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of diabetes mellitus. OBJECTIVE To determine the association between hydroxychloroquine use and the incidence of self-reported diabetes in a cohort of patients with rheumatoid arthritis. DESIGN, SETTING, AND PATIENTS A prospective, multicenter observational study of 4905 adults with rheumatoid arthritis (1808 had taken hydroxychloroquine and 3097 had never taken hydroxychloroquine) and no diagnosis or treatment for diabetes in outpatient university-based and community-based rheumatology practices with 21.5 years of follow-up (January 1983 through July 2004). MAIN OUTCOME MEASURES Diabetes by self-report of diagnosis or hypoglycemic medication use. RESULTS During the observation period, incident diabetes was reported by 54 patients who had taken hydroxychloroquine and by 171 patients who had never taken hydroxychloroquine, with incidence rates of 5.2 per 1000 patient-years of observation compared with 8.9 per 1000 patient-years of observation, respectively (P 
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.298.2.187