Dendritic Cell Immunotherapy for the Treatment of Neoplastic Disease

It has long been promised that dendritic cell immunotherapy would revolutionize the treatment of neoplastic disease. Now, more than 10 years since the publication of the first clinical data, a firmer understanding of immunology and dendritic cell biology is beginning to produce interesting clinical...

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Bibliographic Details
Published in:Biology of blood and marrow transplantation 2006-02, Vol.12 (2), p.113-125
Main Authors: Decker, William K., Xing, Dongxia, Shpall, Elizabeth J.
Format: Article
Language:English
Subjects:
Animals
Cancer Vaccines - immunology
Cancer Vaccines - therapeutic use
Clinical trial
Clinical Trials as Topic
Dendritic cell
Dendritic Cells - immunology
Dendritic Cells - transplantation
Humans
Immunotherapy
Immunotherapy - methods
Neoplasms - immunology
Neoplasms - therapy
T-cell help
T-Lymphocytes, Helper-Inducer - immunology
Toll-Like Receptors - agonists
Toll-Like Receptors - immunology
Vaccine
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Summary:It has long been promised that dendritic cell immunotherapy would revolutionize the treatment of neoplastic disease. Now, more than 10 years since the publication of the first clinical data, a firmer understanding of immunology and dendritic cell biology is beginning to produce interesting clinical results. This article reviews the clinical trials that established many of the concepts with which today’s investigators are achieving improved results, discusses issues in dendritic cell immunotherapy that are currently unresolved, and offers a perspective on the strategies that the authors believe will be important for the design of future vaccine trials, including the use of Toll-like receptor agonists as maturation agents, the accessory use of the plasmacytoid dendritic cell subset, and the maximization of T-cell help.
ISSN:1083-8791
1523-6536
DOI:10.1016/j.bbmt.2005.09.003