Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues

Angiogenesis is now understood to play a major role in the pathology of chronic inflammatory diseases and is indicated to exacerbate disease pathology. Recent evidence shows that angiogenesis is crucial during inflammatory bowel disease (IBD) and in experimental models of colitis. Examination of the...

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Bibliographic Details
Published in:American journal of physiology: Gastrointestinal and liver physiology 2007-07, Vol.293 (1), p.G5-G18
Main Authors: Chidlow, Jr, John H, Shukla, Deepti, Grisham, Matthew B, Kevil, Christopher G
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - therapeutic use
Animals
Antigens, CD - physiology
Cadherins - physiology
Colitis - physiopathology
Colon - chemistry
Disease Models, Animal
Drug therapy
Humans
Immunoglobulins - physiology
Inflammation Mediators - physiology
Inflammatory bowel disease
Inflammatory Bowel Diseases - pathology
Inflammatory Bowel Diseases - therapy
Integrin alphaV - drug effects
Integrin alphaV - physiology
Intercellular Adhesion Molecule-1 - physiology
Intercellular Signaling Peptides and Proteins - physiology
Matrix Metalloproteinases - physiology
Mice
Microcirculation
Mucoproteins - physiology
Neovascularization, Pathologic - prevention & control
Pathology
Platelet Endothelial Cell Adhesion Molecule-1 - metabolism
Vascular Cell Adhesion Molecule-1 - physiology
Vascular Endothelial Growth Factor A - physiology
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Summary:Angiogenesis is now understood to play a major role in the pathology of chronic inflammatory diseases and is indicated to exacerbate disease pathology. Recent evidence shows that angiogenesis is crucial during inflammatory bowel disease (IBD) and in experimental models of colitis. Examination of the relationship between angiogenesis and inflammation in experimental colitis shows that initiating factors for these responses simultaneously increase as disease progresses and correlate in magnitude. Recent studies show that inhibition of the inflammatory response attenuates angiogenesis to a similar degree and, importantly, that inhibition of angiogenesis does the same to inflammation. Recent data provide evidence that differential regulation of the angiogenic mediators involved in IBD-associated chronic inflammation is the root of this pathological angiogenesis. Many factors are involved in this phenomenon, including growth factors/cytokines, chemokines, adhesion molecules, integrins, matrix-associated molecules, and signaling targets. These factors are produced by various vascular, inflammatory, and immune cell types that are involved in IBD pathology. Moreover, recent studies provide evidence that antiangiogenic therapy is a novel and effective approach for IBD treatment. Here we review the role of pathological angiogenesis during IBD and experimental colitis and discuss the therapeutic avenues this recent knowledge has revealed.
ISSN:0193-1857
1522-1547
DOI:10.1152/ajpgi.00107.2007