The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular event...

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Published in:The journal of clinical endocrinology and metabolism 2007-07, Vol.92 (7), p.2532-2537
Main Authors: Dai, Dao-Fu, Lin, Jou-Wei, Kao, Jia-Horng, Hsu, Chih-Neng, Chiang, Fu-Tien, Lin, Jiunn-Lee, Chou, Yi-Hua, Hsu, Kwan-Lih, Tseng, Chuen-Den, Tseng, Yung-Zu, Hwang, Juey-Jen
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
C-Reactive Protein - metabolism
Cohort Studies
Coronary Artery Disease - epidemiology
Coronary Artery Disease - immunology
Disease-Free Survival
Feeding. Feeding behavior
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
Humans
Infection - epidemiology
Infection - immunology
Inflammation - epidemiology
Inflammation - immunology
Male
Metabolic Syndrome - epidemiology
Metabolic Syndrome - immunology
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Risk Factors
Severity of Illness Index
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
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Summary:Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0–5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0–7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2006-2428