Cancer genetics of epigenetic genes

The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HA...

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Bibliographic Details
Published in:Human molecular genetics 2007-04, Vol.16 (R1), p.R28-R49
Main Authors: Miremadi, Ahmad, Oestergaard, Mikkel Z., Pharoah, Paul D.P., Caldas, Carlos
Format: Article
Language:English
Subjects:
DNA (Cytosine-5-)-Methyltransferases - genetics
DNA-Binding Proteins - genetics
Epigenesis, Genetic
Genetic Variation
Genetics
Germ-Line Mutation
Histone Acetyltransferases - genetics
Histone Deacetylases - genetics
Histone Methyltransferases
Histone-Lysine N-Methyltransferase - genetics
Humans
Neoplasms - genetics
Neoplasms - metabolism
Oxidoreductases, N-Demethylating - genetics
Protein Methyltransferases
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Summary:The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/ddm021