Polymorphisms of the GSTM1 and GSTT1 genes in patients with allergic diseases in the Czech population

Background:  Allergic diseases belong to the most common chronic disorders affecting mankind and their prevalence in population is increasing. Several studies have indicated that oxidative stress impairs pulmonary function and makes existing asthma worse. Members of the glutathione‐S‐transferase (GS...

Full description

Saved in:
Bibliographic Details
Published in:Allergy (Copenhagen) 2006-02, Vol.61 (2), p.265-267
Main Authors: Holla, L. I., Stejskalova, A., Vasku, A.
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
allergy
asthma
Asthma - genetics
Biological and medical sciences
Czech Republic
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
gene
Gene Frequency
Genetic Predisposition to Disease
Genotype
Glutathione Transferase - genetics
glutathione‐ S‐transferase
Humans
Hypersensitivity - genetics
Immunopathology
Male
Medical sciences
Polymorphism, Genetic
reactive oxygen species
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background:  Allergic diseases belong to the most common chronic disorders affecting mankind and their prevalence in population is increasing. Several studies have indicated that oxidative stress impairs pulmonary function and makes existing asthma worse. Members of the glutathione‐S‐transferase (GST) superfamily of genes are important in protection of cells from reactive oxygen species. Aims of the study:  Relationships among allergic diseases including asthma and variations in the GST mu (GSTM1) and GST theta (GSTT1) genes were investigated in 1006 Caucasian subjects. Methods:  The multiplex polymerase chain reaction protocol was used for simultaneous amplification of both genes for molecular analysis. Genotype frequencies among patients and controls were assessed and the associations of the genotypes with intermediary phenotypes of allergy were statistically determined. Results:  The frequencies of GST null genotypes did not differ significantly between patients with allergic diseases (or asthma alone) and healthy controls. However, when compared with patients homozygous or heterozygous for GSTM1 functional allele, asthmatics carrying both GSTM1 null alleles displayed significantly worse lung function, assessed by forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) ratio (Tiffenau index), (P 
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2006.01000.x