Inflammation in Renal Disease

Inflammation is a component of the major modifiable risk factors in renal disease. Elevated high-sensitivity C-reactive protein (hs-CRP) levels have been shown to predict all-cause and cardiovascular mortality in patients dependent on dialysis and to predict worsening renal function in subjects with...

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Bibliographic Details
Published in:The American journal of cardiology 2006-01, Vol.97 (2), p.20-27
Main Author: Vidt, Donald G.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers - blood
C-Reactive Protein - metabolism
Cardiology. Vascular system
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Drug therapy
Global Health
Humans
Incidence
Inflammation - blood
Kidney diseases
Kidney Diseases - blood
Kidney Diseases - complications
Medical sciences
Proteins
Risk Factors
Statins
Survival Rate
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Summary:Inflammation is a component of the major modifiable risk factors in renal disease. Elevated high-sensitivity C-reactive protein (hs-CRP) levels have been shown to predict all-cause and cardiovascular mortality in patients dependent on dialysis and to predict worsening renal function in subjects without overt renal disease. Levels of hs-CRP are also predictive of hypertension, a major risk factor for renal disease, across all levels of blood pressure in subjects without initial hypertension. Many of the treatments used in patients with renal disease exert anti-inflammatory activities that constitute or contribute to their therapeutic effects. A number of studies have indicated that statin therapy exerts a renoprotective effect that is possibly mediated by anti-inflammatory activities.
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.11.012