Diagnostic potential of circulating natriuretic peptides in chronic kidney disease

Background. Measurement of natriuretic peptides, particularly brain natriuretic peptide (BNP) is an established method for the diagnosis of cardiovascular disorders, chiefly left ventricular (LV) dysfunction. The influence of renal function on the diagnostic utility of natriuretic peptides is unclea...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2006-02, Vol.21 (2), p.402-410
Main Authors: Mark, Patrick B., Stewart, Graham A., Gansevoort, Ron T., Petrie, Colin J., McDonagh, Theresa A., Dargie, Henry J., Rodger, R. Stuart C., Jardine, Alan G.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Atrial Natriuretic Factor - blood
atrial natriuretic peptide
Biological and medical sciences
brain natriuretic peptide
Cardiomyopathies - blood
Cardiomyopathies - diagnosis
cardiomyopathy
Chronic Disease
chronic renal failure
Cross-Sectional Studies
Emergency and intensive care: renal failure. Dialysis management
Female
Humans
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - diagnosis
Intensive care medicine
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidneys
left ventricular hypertrophy
Male
Medical sciences
Middle Aged
Natriuretic Peptide, Brain - blood
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Renal failure
Tumors of the urinary system
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Summary:Background. Measurement of natriuretic peptides, particularly brain natriuretic peptide (BNP) is an established method for the diagnosis of cardiovascular disorders, chiefly left ventricular (LV) dysfunction. The influence of renal function on the diagnostic utility of natriuretic peptides is unclear. Methods. We performed a cross-sectional study of 296 patients with renal disease but no history of cardiac disease using echocardiography to assess LV mass and function. Circulating levels of atrial natriuretic peptide (ANP) and BNP were also measured. Results. The incidence of LV hypertrophy increased with progressive renal dysfunction; from 39% in patients with near-normal renal function, to 80% in renal transplant patients. There was a negative correlation between both ANP and BNP, and glomerular filtration rate (GFR) (ANP: r = −0.28, P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfi187