Prospective X-ray densitometry and ultrasonography study of the hand bones of patients with rheumatoid arthritis of recent onset

Objective. Bone demineralization observed in early rheumatoid arthritis is not easily measured. To measure bone loss and to discriminate between rheumatoid arthritis and other rheumatic diseases, we used two methods: dual-energy X-ray absorptiometry and ultrasonography. Methods. From a population-ba...

Full description

Saved in:
Bibliographic Details
Published in:Joint, bone, spine : revue du rhumatisme bone, spine : revue du rhumatisme, 2001-02, Vol.68 (1), p.34-42
Main Authors: Daragon, Alain, Krzanowska, Katarzyna, Vittecoq, Olivier, Ménard, Jean-François, Hau, Isabelle, Jouen-Beades, Fabienne, Lesage, Corinne, Bertho, Jean-Marie, Tron, François, Le Loët, Xavier
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Aged
Arthritis, Rheumatoid - diagnostic imaging
Arthritis, Rheumatoid - metabolism
Arthritis, Rheumatoid - physiopathology
Blood Cells - immunology
Bone and Bones - diagnostic imaging
Bone and Bones - metabolism
Bone Density
Cells, Cultured
cytokines
Cytokines - blood
Disease Progression
Female
Hand
Humans
Male
Middle Aged
Prospective Studies
rheumatoid arthritis
Severity of Illness Index
Ultrasonography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. Bone demineralization observed in early rheumatoid arthritis is not easily measured. To measure bone loss and to discriminate between rheumatoid arthritis and other rheumatic diseases, we used two methods: dual-energy X-ray absorptiometry and ultrasonography. Methods. From a population-based recruitment, 32 patients with early peripheral polyarthritis (median disease duration: 4 months) were studied. Clinical, laboratory, functional, hand-bone assessments were made at the entry and at months 6 and 12. Bone X-ray densitometry measurements were made on 16 areas of the hand. Speed of sound was measured across the proximal phalanges of the four fingers. X-rays of both hands were scored according to the modified Sharp’s score. At 12 months, patients were classified as rheumatoid arthritis ( N = 15 ; 9 F) or as other rheumatic diseases. Results. We found: 1) significantly decreased bone mineral density (BMD) of the whole hand, in the rheumatoid arthritis group versus the other rheumatic diseases group, at 6 and 12 months ( P 
ISSN:1297-319X
1778-7254
DOI:10.1016/S1297-319X(00)00227-X