International workshop on immune tolerance induction: consensus recommendations

Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of scientific evidence to guide therapeutic decision-making. In an effort to provide direction for physicians and he...

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Bibliographic Details
Published in:Haemophilia : the official journal of the World Federation of Hemophilia 2007-07, Vol.13 (s1), p.1-22
Main Authors: DIMICHELE, D. M., HOOTS, W. K., PIPE, S. W., RIVARD, G. E., SANTAGOSTINO, E.
Format: Article
Language:English
Subjects:
Blood Coagulation Factor Inhibitors - immunology
Catheters, Indwelling
Child, Preschool
Cost-Benefit Analysis
Equipment Failure
factor IX
Factor IX - administration & dosage
Factor IX - antagonists & inhibitors
Factor IX - immunology
Factor IX - pharmacokinetics
factor VIII
Factor VIII - administration & dosage
Factor VIII - antagonists & inhibitors
Factor VIII - immunology
Factor VIII - pharmacokinetics
hemophilia A
Hemophilia A - immunology
Hemophilia A - therapy
hemophilia B
Humans
immune tolerance induction
Immunosuppression - methods
Infant
Infection - complications
Infection - immunology
inhibitors
Meta-Analysis as Topic
Randomized Controlled Trials as Topic
Risk Factors
Treatment Failure
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Summary:Although immune tolerance induction (ITI) has been used for 30 years to eliminate inhibitors and restore normal factor pharmacokinetics in patients with hemophilia, there is a paucity of scientific evidence to guide therapeutic decision-making. In an effort to provide direction for physicians and hemophilia treatment center staff members, an international panel of hemophilia opinion leaders met to develop consensus recommendations for ITI in patients with severe and mild hemophilia A and hemophilia B. These recommendations draw on the available published literature and the collective clinical experience of the group and are rated based on the level of supporting evidence.
ISSN:1351-8216
1365-2516
DOI:10.1111/j.1365-2516.2007.01497.x