Long-Term Safety and Efficacy of a Cholesterol-Lowering Diet in Children With Elevated Low-Density Lipoprotein Cholesterol: Seven-Year Results of the Dietary Intervention Study in Children (DISC)

Diets reduced in fat and cholesterol are recommended for children over 2 years of age, yet long-term safety and efficacy are unknown. This study tests the long-term efficacy and safety of a cholesterol-lowering dietary intervention in children. Six hundred sixty-three children 8 to 10 years of age w...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2001-02, Vol.107 (2), p.256-264
Main Authors: Obarzanek, Eva, Kimm, Sue Y. S, Barton, Bruce A, Van Horn, Linda, Kwiterovich Jr, Peter O, Simons-Morton, Denise G, Hunsberger, Sally A, Lasser, Norman L, Robson, Alan M, Franklin Jr, Frank A, Lauer, Ronald M, Stevens, Victor J, Friedman, Lisa Aronson, Dorgan, Joanne F, Greenlick, Merwyn R, on Behalf of DISC Collaborative Research Group
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Body Height
Body Mass Index
Child
Children
Children & youth
Cholesterol
Cholesterol - blood
Cholesterol, LDL - blood
Diet
Diet therapy
Diet, Fat-Restricted - adverse effects
Dietary Fats - administration & dosage
Energy Intake
Female
Ferritins - blood
Follow-Up Studies
Food and nutrition
Health
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - diet therapy
Hypercholesterolemia - physiopathology
Hypercholesterolemia in children
Male
Medical sciences
Miscellaneous
Nutritional Status
Oils & fats
Pediatric hypercholesterolemia
Pediatrics
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Triglycerides - blood
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Summary:Diets reduced in fat and cholesterol are recommended for children over 2 years of age, yet long-term safety and efficacy are unknown. This study tests the long-term efficacy and safety of a cholesterol-lowering dietary intervention in children. Six hundred sixty-three children 8 to 10 years of age with elevated low-density lipoprotein cholesterol (LDL-C) were randomized to a dietary intervention or usual care group, with a mean of 7.4 years' follow-up. The dietary behavioral intervention promoted adherence to a diet with 28% of energy from total fat,
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.107.2.256